Implants composed of digoxin and poly(ε-caprolactone) : development, characterization, anti-proliferative and anti-angiogenic activities.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorRodrigues, Felipe Fernandes-
Autor(es): dc.creatorBraz, Wilson Rodrigues-
Autor(es): dc.creatorPerasoli, Fernanda Barçante-
Autor(es): dc.creatorFerreira, Letícia Gonçalves Resende-
Autor(es): dc.creatorBarbosa, Leandro Augusto de Oliveira-
Autor(es): dc.creatorSilva, Gisele Rodrigues da-
Data de aceite: dc.date.accessioned2025-08-21T15:43:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:28Z-
Data de envio: dc.date.issued2019-04-17-
Data de envio: dc.date.issued2019-04-17-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11059-
Fonte completa do material: dc.identifierhttps://www.ingentaconnect.com/contentone/govi/pharmaz/2017/00000072/00000007/art00002-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022568-
Descrição: dc.descriptionDrug delivery systems could be applied to locally treat cervical cancer, thus preventing the drawbacks of conventional therapy. In this study, anti-proliferative and anti-angiogenic effects of digoxin incorporated into poly(ε-caprolactone) implants were evaluated, aiming at the local treatment of cervical cancer. Implants were characterized, and the in vitro release profile of digoxin was demonstrated. Anti-proliferative and anti-angiogenic activities of digoxin were investigated by using chorioallantoic membrane and human cervix carcinoma (HeLa) cells, respectively. The chemical structure of digoxin and the semi-crystalline nature of poly(ε-caprolactone) were preserved after designing implants. The hydrophobicity of drug and polymer as well as the semi-crystalline structure provided a controlled diffusion of digoxin from implants. Digoxin released from implantable devices exhibited anti-proliferative activity against HeLa cells. The anti-angiogenic effect was also shown. Finally, implants composed of digoxin and poly(ε-caprolactone) could be applied as a therapeutic alternative to treat the early stage of cervical cancer, once they were able to locally control the release of this anti-angiogenic and anti-proliferative drug, minimizing its systemic side effects and toxicity.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleImplants composed of digoxin and poly(ε-caprolactone) : development, characterization, anti-proliferative and anti-angiogenic activities.-
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