Crossing of the cystic barriers of Toxoplasma gondii by the fluorescent coumarin tetra-cyclopeptide.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorDard, Céline-
Autor(es): dc.creatorLeforestier, Baptiste-
Autor(es): dc.creatorHilário, Flaviane Francisco-
Autor(es): dc.creatorTraoré, Mohamed Dit Mady-
Autor(es): dc.creatorLespinasse, Marie-Ange-
Autor(es): dc.creatorPérès, Basile-
Autor(es): dc.creatorMolina, Marie-Carmen-
Autor(es): dc.creatorFreitas, Rossimiriam Pereira de-
Autor(es): dc.creatorMilet, Anne-
Autor(es): dc.creatorMaubon, Danièle-
Autor(es): dc.creatorWong, Yung-Sing-
Data de aceite: dc.date.accessioned2025-08-21T15:43:25Z-
Data de disponibilização: dc.date.available2025-08-21T15:43:25Z-
Data de envio: dc.date.issued2023-05-19-
Data de envio: dc.date.issued2023-05-19-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16613-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/molecules26247506-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022544-
Descrição: dc.descriptionFR235222 is a natural tetra-cyclopeptide with a strong inhibition effect on histone deacety- lases, effective on mammalian cells as well as on intracellular apicomplexan parasites, such as Toxo- plasma gondii, in the tachyzoite and bradyzoite stages. This molecule is characterized by two parts: the zinc-binding group, responsible for the binding to the histone deacetylase, and the cyclic tetrapeptide moiety, which plays a crucial role in cell permeability. Recently, we have shown that the cyclic tetrapeptide coupled with a fluorescent diethyl-amino-coumarin was able to maintain properties of cellular penetration on human cells. Here, we show that this property can be extended to the crossing of the Toxoplasma gondii cystic cell wall and the cell membrane of the parasite in its bradyzoite form, while maintaining a high efficacy as a histone deacetylase inhibitor. The investigation by molecular modeling allows a better understanding of the penetration mechanism.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectHistone deacetylase-
Palavras-chave: dc.subjectBradyzoite-
Palavras-chave: dc.subjectCell-permeable agent-
Palavras-chave: dc.subjectMolecular dynamics-
Título: dc.titleCrossing of the cystic barriers of Toxoplasma gondii by the fluorescent coumarin tetra-cyclopeptide.-
Aparece nas coleções:Repositório Institucional - UFOP

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