High-resolution mass spectrometry identification and characterization of flavonoids from Fridericia chica leaves extract with anti-arbovirus activity.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCruz, Ana Flávia Gomes da-
Autor(es): dc.creatorReis, Adriana Cotta Cardoso-
Autor(es): dc.creatorSousa, Jordano Augusto Carvalho-
Autor(es): dc.creatorVaz, Luana Beatriz Araújo-
Autor(es): dc.creatorSilva, Breno de Mello-
Autor(es): dc.creatorMagalhães, Cíntia Lopes de Brito-
Autor(es): dc.creatorKohlhoff, Markus-
Autor(es): dc.creatorOliveira, Alaíde Braga de-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Data de aceite: dc.date.accessioned2025-08-21T15:42:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:42:37Z-
Data de envio: dc.date.issued2023-10-10-
Data de envio: dc.date.issued2023-10-10-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17553-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/molecules27186043-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1022192-
Descrição: dc.descriptionPlant extracts are complex mixtures that are difficult to characterize, and mass spectrometry is one of the main techniques currently used in dereplication processes. Fridericia chica is a species with medicinal uses in Latin American countries, used in the treatment of inflammatory and infectious diseases. Extracts of this plant species are characterized by the presence of anthocyanidins. In this study, using high-resolution mass spectrometry coupled with liquid chromatography, it was possible to determine the molecular formula of thirty-nine flavonoids. Fragmentation analysis, ultraviolet spectrum and nuclear magnetic resonance data allowed the partial characterization of the structures of these compounds. The spectral dataset allowed the identification of a series of flavones in addition to the desoxyanthocyanidins common in extracts of the species. The occurrence of some of the proposed structures is uncommon in extracts of species of the Bignoniaceae family, and they are reported for the first time in the extract of this species. Quantitative analyses of total flavonoids confirmed the high content of these constituents in the species, with 4.09 ± 0.34 mg/g of dry plant material. The extract under study showed low in vitro cytotoxicity with CC50 ≥ 296.7 ± 1.4 μg/mL for Vero, LLC-MK2 and MRC-5 cell lines. In antiviral activity assays, inhibition of the cytopathic effects of Dengue, Zika and Mayaro viruses was observed, with EC50 values ranging between 30.1 and 40.9 μg/mL. The best result was observed against the Mayaro virus, with an EC50 of 30.1 μg/mL.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectArrabidaea chica-
Palavras-chave: dc.subjectBignoniaceae-
Palavras-chave: dc.subjectAnti-dengue activity-
Título: dc.titleHigh-resolution mass spectrometry identification and characterization of flavonoids from Fridericia chica leaves extract with anti-arbovirus activity.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.