Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCorrêa, Paulo Roberto Ceridóreo-
Autor(es): dc.creatorMiranda, Roqueline Rodrigues Silva de-
Autor(es): dc.creatorDuarte, Lucienir Pains-
Autor(es): dc.creatorSilva, Grácia Divina de Fátima-
Autor(es): dc.creatorVieira Filho, Sidney Augusto-
Autor(es): dc.creatorOkuma, Adriana Akemi-
Autor(es): dc.creatorCarazza, Fernando-
Autor(es): dc.creatorMorgado Díaz, José Andrés-
Autor(es): dc.creatorPinge Filho, Phileno-
Autor(es): dc.creatorYamauchi, Lucy Megumi-
Autor(es): dc.creatorNakamura, Celso Vataru-
Autor(es): dc.creatorOgatta, Sueli Fumie Yamada-
Data de aceite: dc.date.accessioned2025-08-21T15:42:09Z-
Data de disponibilização: dc.date.available2025-08-21T15:42:09Z-
Data de envio: dc.date.issued2017-03-31-
Data de envio: dc.date.issued2017-03-31-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7506-
Fonte completa do material: dc.identifierhttp://www.tandfonline.com/doi/full/10.1179/2047773212Y.0000000002-
Fonte completa do material: dc.identifierhttps://doi.org/10.1179/2047773212Y.0000000002-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1021978-
Descrição: dc.descriptionWe report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl- 39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleAntimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.-
Aparece nas coleções:Repositório Institucional - UFOP

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