Synthesis of 3,5-Diarylisoxazole derivatives and evaluation of in vitro trypanocidal activity.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSouza, Aline Aparecida Nunes de-
Autor(es): dc.creatorXavier, Viviane F.-
Autor(es): dc.creatorCoelho, Gleicekelly Silva-
Autor(es): dc.creatorSales Júnior, Policarpo Ademar-
Autor(es): dc.creatorRomanha, Alvaro José-
Autor(es): dc.creatorMurta, Silvane Maria Fonseca-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorTaylor, Jason Guy-
Data de aceite: dc.date.accessioned2025-08-21T15:41:36Z-
Data de disponibilização: dc.date.available2025-08-21T15:41:36Z-
Data de envio: dc.date.issued2018-03-13-
Data de envio: dc.date.issued2018-03-13-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9613-
Fonte completa do material: dc.identifierhttps://doi.org/10.21577/0103-5053.20170137-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1021746-
Descrição: dc.descriptionChagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazoles were obtained by reaction of flavones and hydroxylamine and either alkylated at the free hydroxyl group and/or nitrated at the isoxazole ring. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as a reference compound for the in vitro assay and mammalian L929 cells were employed to evaluate cytotoxicity. A majority of the compounds tested were very active and the most active isoxazole against amastigote and trypomastigotes of T. cruzi was slightly more potent than the current medicine benznidazole.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsJournal of the Brazilian Chemical Society permite que a UFOP deposite uma cópia em formato eletrônico dos artigos de seus alunos e professores publicados neste periódico no Repositório Institucional. Contato via email em 13 set. 2013.-
Palavras-chave: dc.subjectIsoxazole-
Palavras-chave: dc.subjectTrypomastigote-
Palavras-chave: dc.subjectAmastigote-
Palavras-chave: dc.subjectAzole-
Título: dc.titleSynthesis of 3,5-Diarylisoxazole derivatives and evaluation of in vitro trypanocidal activity.-
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