Ru(II)-thymine complex causes cell growth inhibition and induction of caspase-mediated apoptosis in human promyelocytic leukemia HL-60 cells.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Maiara de Souza-
Autor(es): dc.creatorSantana, Adila Angélica Dantas de-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorSoares, Milena Botelho Pereira-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Autor(es): dc.creatorBezerra, Daniel Pereira-
Data de aceite: dc.date.accessioned2025-08-21T15:41:18Z-
Data de disponibilização: dc.date.available2025-08-21T15:41:18Z-
Data de envio: dc.date.issued2019-05-08-
Data de envio: dc.date.issued2019-05-08-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11227-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms19061609-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1021606-
Descrição: dc.descriptionRuthenium-based compounds represent a class of potential antineoplastic drugs. Recently, we designed, synthesized, and identified the Ru(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh = triphenylphosphine, Thy = thymine and bipy = 2,2′-bipyridine) as a potent cytotoxic agent with the ability to bind to DNA and human and bovine serum albumins. In this study, the underlying cytotoxic mechanism of the [Ru(PPh3)2(Thy)(bipy)]PF6 complex was assessed. This complex displayed potent cytotoxicity in different cancer cell lines; the morphology that is associated with apoptotic cell death, increased internucleosomal DNA fragmentation without cell membrane permeability, loss of the mitochondrial transmembrane potential, increased phosphatidylserine externalization, and caspase-3 activation were observed in human promyelocytic leukemia HL-60 cells that were treated with the complex. Moreover, pretreatment of HL-60 cells with Z-VAD(OMe)-FMK, a pan-caspase inhibitor, partially reduced the apoptosis that was induced by the complex, indicating that the apoptotic cell death occurred through a caspase-mediated pathway. In conclusion, the [Ru(PPh3)2(Thy)(bipy)]PF6 complex displays potent cytotoxicity to different cancer cells and induces caspase-mediated apoptosis in HL-60 cells.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Fonte: o próprio artigo.-
Palavras-chave: dc.subjectRuthenium-
Palavras-chave: dc.subjectCytotoxicity-
Título: dc.titleRu(II)-thymine complex causes cell growth inhibition and induction of caspase-mediated apoptosis in human promyelocytic leukemia HL-60 cells.-
Aparece nas coleções:Repositório Institucional - UFOP

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