Ruthenium(II) complexes of 1,3-thiazolidine-2-thione : cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole

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Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorSilva, Monize Martins da-
Autor(es): dc.creatorGraminha, Angelica Ellen-
Autor(es): dc.creatorMeira, Cássio Santana-
Autor(es): dc.creatorSantos, Jamyle Andrade Ferreira dos-
Autor(es): dc.creatorMoreira, Diogo Rodrigo de Magalhães-
Autor(es): dc.creatorSoares, Milena Botelho Pereira-
Autor(es): dc.creatorPoelhsitz, Gustavo Von-
Autor(es): dc.creatorCastellano, Eduardo Ernesto-
Autor(es): dc.creatorBloch Junior, Carlos-
Autor(es): dc.creatorCominetti, Márcia Regina-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:40:51Z-
Data de disponibilização: dc.date.available2025-08-21T15:40:51Z-
Data de envio: dc.date.issued2016-11-07-
Data de envio: dc.date.issued2016-11-07-
Data de envio: dc.date.issued2016-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7067-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.jinorgbio.2015.12.024-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1021413-
Descrição: dc.descriptionThree newmixed and mononuclear Ru(II) complexes containing 1,3-thiazolidine-2-thione (tzdtH) were synthesized and characterized by spectroscopic analysis, molar conductivity, cyclic voltammetry, high-resolution electrospray ionization mass spectra and X-ray diffraction. The complexes presented unique stereochemistry and the proposed formulae are: [Ru(tzdt)(bipy)(dppb)]PF6 (1), cis-[Ru(tzdt)2(PPh3)2] (2) and trans- [Ru(tzdt)(PPh3)2(bipy)]PF6 (3), where dppb = 1,4-bis(diphenylphosphino)butane and bipy= 2,2′-bipyridine. These complexes demonstrated strong cytotoxicity against cancer cell lines when compared to cisplatin. Specifically, complex 2 was the most potent cytotoxic agent against MCF-7 breast cells, while complexes 1 and 3 were more active in DU-145 prostate cells. Binding of complexes to ctDNA was determined by UV–vis titration and viscosity measurements and revealed binding constant (Kb) values in range of 1.0–4.9 × 103 M−1, which are characteristic of compounds possessing weak affinity to ctDNA. In addition, these complexes presented antiparasitic activity against Trypanosoma cruzi. Specifically, complex 3 demonstrated strong potency, moderate selectivity index and acted in synergism with the approved antiparasitic drug, benznidazole. Additionally, complex 3 caused parasite cell death through a necrotic process. In conclusion, we demonstrated that Ru(II) complexes have powerful pharmacological activity, while the metal-free tzdtH does not provoke the same outcome.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languagept_BR-
Direitos: dc.rightsaberto-
Direitos: dc.rightsO periódico Journal of Inorganic Biochemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3958741353996.-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleRuthenium(II) complexes of 1,3-thiazolidine-2-thione : cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole-
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