Oncogenic role of lncRNA SBF2-AS1 in bladder cancer.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Edymara dos Anjos-
Autor(es): dc.creatorAlmeida, Tamires Cunha-
Autor(es): dc.creatorSilva, Glenda Nicioli da-
Data de aceite: dc.date.accessioned2025-08-21T15:40:25Z-
Data de disponibilização: dc.date.available2025-08-21T15:40:25Z-
Data de envio: dc.date.issued2025-02-04-
Data de envio: dc.date.issued2025-02-04-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19703-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0378111924009429-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.gene.2024.149061-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1021230-
Descrição: dc.descriptionIntroduction: Bladder cancer is a malignant neoplasm with increasing incidence rates. LncRNAs play an important role in cancer, including development, prognosis, and response to therapies. It is known that lncRNA SBF2-AS1 was associated with cell proliferation and worse prognosis in various tumor types, but its role remains incompletely understood in bladder cancer. In this context, our objective was to evaluate the effect of lncRNA SBF2-AS1 silencing on bladder cancer cells. Methods: J82 and UM-UC-3 high-grade bladder tumor cells were treated with two siRNAs specific for SBF2-AS1 to evaluate cytotoxicity, clonogenic survival, morphology, cell migration, and cell cycle progression. Results: Expression inhibition of SBF2-AS1 resulted in cytotoxicity, morphological changes, and decreased clone formation and cell migration. Cell cycle alterations were not observed. Conclusion: Our study revealed that SBF2-AS1 plays an oncogenic role and holds promise as a potential target for the treatment of bladder cancer.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectBladder cancer-
Palavras-chave: dc.subjectLong non-coding RNAs-
Palavras-chave: dc.subjectOncogenic role-
Título: dc.titleOncogenic role of lncRNA SBF2-AS1 in bladder cancer.-
Aparece nas coleções:Repositório Institucional - UFOP

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