A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study.

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Autor(es): dc.creatorFreitas, Renata Nascimento de-
Autor(es): dc.creatorKay-Tee, Khaw-
Autor(es): dc.creatorWu, Kelvin-
Autor(es): dc.creatorBowman, Richard-
Autor(es): dc.creatorJeffery, Hannah-
Autor(es): dc.creatorLuben, Robert-
Autor(es): dc.creatorWareham, Nick J.-
Autor(es): dc.creatorBingham, Sheila A.-
Data de aceite: dc.date.accessioned2025-08-21T15:39:16Z-
Data de disponibilização: dc.date.available2025-08-21T15:39:16Z-
Data de envio: dc.date.issued2017-05-11-
Data de envio: dc.date.issued2017-05-11-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7715-
Fonte completa do material: dc.identifierhttps://doi.org/10.1017/S0007114510001145-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1020732-
Descrição: dc.descriptionThe objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl- coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available. Genotype frequencies and allele distributions for 23 011 participants were: TT 95·65 %, TG 4·29% and GG 0·06 %; T 97·8% and G 2·2 %. In regression analyses, the TG þ GG group showed a significant positive relationship between TAG and SFA intake (þ0·11 (95% CI 0·02, 0·20) mmol TAG/l; P¼0·017; per 3% SFA energy increase) while the TT individuals showed no change in the TAG levels related to SFA intake (20·0007 (95% CI 20·02, 0·02) mmol TAG/l; P¼0·99). TG þ GG individuals showed an inverse relationship between TAG and fibre intake higher (20·14 (95% CI 20·22, 20·05) mmol TAG/l than the TT group (20·04 (95% CI 20·06, 20·02) mmol TAG/l). In both cases the respective coefficient regressions of TAG were different between the genotype groups (Z ¼ 2·27, P¼0·023 for SFA intake; Z ¼ 2·19, P¼0·029 for fibre intake). Individuals carrying the G allele may show a greater response in lower TAG levels with reduced SFA intake and increased fibre intake compared with those homozygous for the T allele. The effectiveness of different dietary interventions to control serum lipids may vary according to HMGCR genotype.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsO periódico British Journal of Nutrition permite o arquivamento da versão PDF do editor em repositório institucional. Fonte: Sherpa/Romeo <http://sherpa.ac.uk/romeo/search.php?issn=0007-1145>. Acesso em: 19 nov. 2019.-
Palavras-chave: dc.subjectSerum lipids-
Palavras-chave: dc.subjectDietary fat-
Palavras-chave: dc.subjectDietary fibre-
Título: dc.titleA single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study.-
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