cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II) : synthesis, molecular structure and its interaction with human and bovine serum albumin.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorPérez, Hiram-
Autor(es): dc.creatorPlutín Stevens, Ana María-
Autor(es): dc.creatorRamos Cairo, Raúl-
Autor(es): dc.creatorMocelo, Raúl-
Autor(es): dc.creatorCastellano, Eduardo Ernesto-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:39:00Z-
Data de disponibilização: dc.date.available2025-08-21T15:39:00Z-
Data de envio: dc.date.issued2020-06-18-
Data de envio: dc.date.issued2020-06-18-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12370-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.arabjc.2015.10.006-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1020614-
Descrição: dc.descriptionIn this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C–H⋯C, C–H⋯S and H⋯H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, Kb, presenting values of around 105 M−1 and 104 M−1, respectively. Thermodynamic parameters (ΔG, ΔH and ΔS) suggest spontaneous interactions between complex and the proteins.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Fonte: o próprio artigo.-
Palavras-chave: dc.subjectPlatinum complex-
Palavras-chave: dc.subjectBenzoylthiourea-
Palavras-chave: dc.subjectHirshfeld surface-
Título: dc.titlecis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II) : synthesis, molecular structure and its interaction with human and bovine serum albumin.-
Aparece nas coleções:Repositório Institucional - UFOP

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