DNA ddduct formation in the lungs and brain of rats exposed to low concentrations of [13C2]‑Acetaldehyde.

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Autor(es): dc.creatorSanchez, Angelica Bianchini-
Autor(es): dc.creatorGarcia, Camila Carrião Machado-
Autor(es): dc.creatorFreitas, Florencio Porto-
Autor(es): dc.creatorBatista, Guilherme Lopes-
Autor(es): dc.creatorLopes, Fernando Silva-
Autor(es): dc.creatorCarvalho, Victor Henrique-
Autor(es): dc.creatorRonsein, Graziella Eliza-
Autor(es): dc.creatorGutz, Ivano Gebhardt Rolf-
Autor(es): dc.creatorMascio, Paolo Di-
Autor(es): dc.creatorMedeiros, Marisa Helena Gennari de-
Data de aceite: dc.date.accessioned2025-08-21T15:38:25Z-
Data de disponibilização: dc.date.available2025-08-21T15:38:25Z-
Data de envio: dc.date.issued2019-04-04-
Data de envio: dc.date.issued2019-04-04-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/10946-
Fonte completa do material: dc.identifierhttps://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00016-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1020408-
Descrição: dc.descriptionAir pollution is a major environmental risk for human health. Acetaldehyde is present in tobacco smoke and vehicle exhaust. In this study, we show that [13C2]-acetaldehyde induces DNA modification with the formation of isotopically labeled 1,N2-propano-2′-deoxyguanosine adducts in the brain and lungs of rats exposed to concentrations of acetaldehyde found in the atmosphere of megacities. The adduct, with the addition of two molecules of isotopically labeled acetaldehyde [13C4]-1,N2-propano-dGuo, was detected in the lung and brain tissues of exposed rats by micro-HPLC/MS/MS. Structural confirmation of the products was unequivocally performed by nano-LC/ESI+-HRMS3 analyses. DNA modifications induced by acetaldehyde have been regarded as a key factor in the mechanism of mutagenesis and may be involved in the cancer risks associated with air pollution.-
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Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleDNA ddduct formation in the lungs and brain of rats exposed to low concentrations of [13C2]‑Acetaldehyde.-
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