Vitamin D deficiency and VDR gene polymorphism FokI (rs2228570) are associated with diabetes mellitus in adults : COVID-Inconfidentes study.

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Autor(es): dc.creatorMoura, Samara Silva de-
Autor(es): dc.creatorMenezes Júnior, Luiz Antônio Alves de-
Autor(es): dc.creatorRocha, Ana Maria Sampaio-
Autor(es): dc.creatorBatista, Aline Priscila-
Autor(es): dc.creatorSabião, Thaís da Silva-
Autor(es): dc.creatorMenezes, Mariana Carvalho de-
Autor(es): dc.creatorCoelho, George Luiz Lins Machado-
Autor(es): dc.creatorCarraro, Júlia Cristina Cardoso-
Autor(es): dc.creatorMeireles, Adriana Lúcia-
Data de aceite: dc.date.accessioned2025-08-21T15:38:19Z-
Data de disponibilização: dc.date.available2025-08-21T15:38:19Z-
Data de envio: dc.date.issued2025-02-18-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19764-
Fonte completa do material: dc.identifierhttps://doi.org/10.1186/s13098-024-01328-6-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1020369-
Descrição: dc.descriptionBackground: Diabetes mellitus is a chronic and multifactorial condition, including environmental risk factors such as lifestyle habits and genetic conditions. Objective: We aimed to evaluate the association of VDR gene polymorphism (rs2228570) FokI and vitamin D levels with diabetes in adults. Methods: Cross-sectional population-based study in adults, conducted from October to December 2020 in two Brazilian cities. The outcome variable was diabetes, defined as glycated hemoglobin ≥ 6.5% or self-report medical diagnosis or use of oral hypoglycemic drugs. Vitamin D (25-hydroxyvitamin D) was measured by indirect electrochemiluminescence, and classified as deficiency when 25(OH)D < 20 ng/mL. All participants were genotyped for VDR FokI polymorphism by qPCR and classified as homozygous mutant (ff or GG), heterozygous (Ff or AG), or homozygous wild (FF or AA). A combined analysis between the FokI polymorphism and vitamin D levels with diabetes was also examined. A directed acyclic graph (DAG) was used to select minimal and sufficient adjustment for confounding variables by the backdoor criterion. Results: The prevalence of DM was 9.4% and vitamin D deficiency (VDD) was 19.9%. The genotype distribution of FokI polymorphism was 9.9% FF, 44.8% Ff, and 45.3% ff. It was possible to verify a positive association between vitamin D deficiency and DM (OR = 2.19; 95% CI: 1.06–4.50). Individuals with the altered allele (ff ) had a 1.78 higher prevalence of DM (OR: 1.78; 95% CI; 1.10–2.87). Combined analyses, individuals with vitamin D deficiency and one or two copies of the altered FokI allele had a higher prevalence of DM (Ff + ff: OR: 1.67; 95% CI; 1.07–2.61; ff: OR: 3.60; 95% CI; 1.40–9.25). Conclusion: Our data suggest that vitamin D deficiency and FokI polymorphism are associated with DM.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modifed the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. Fonte: PDF do artigo.-
Palavras-chave: dc.subjectSingle-nucleotide polymorphism-
Palavras-chave: dc.subjectVitamin D receptor-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectGlycated hemoglobin-
Palavras-chave: dc.subjectPopulation genetics-
Título: dc.titleVitamin D deficiency and VDR gene polymorphism FokI (rs2228570) are associated with diabetes mellitus in adults : COVID-Inconfidentes study.-
Aparece nas coleções:Repositório Institucional - UFOP

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