Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorFreire, Vitória-
Autor(es): dc.creatorBarbosa, Marília Imaculada Frazão-
Autor(es): dc.creatorBezerra, Daniel Pereira-
Autor(es): dc.creatorBomfim, Larissa Mendes-
Autor(es): dc.creatorMoreira, Diogo Rodrigo de Magalhães-
Autor(es): dc.creatorSoares, Milena Botelho Pereira-
Autor(es): dc.creatorEllena, Javier Alcides-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:37:53Z-
Data de disponibilização: dc.date.available2025-08-21T15:37:53Z-
Data de envio: dc.date.issued2019-05-08-
Data de envio: dc.date.issued2019-05-08-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11226-
Fonte completa do material: dc.identifierhttps://pubs.rsc.org/en/content/articlelanding/2018/NJ/C7NJ04368F#!divAbstract-
Fonte completa do material: dc.identifierhttp://doi.org/10.1039/c7nj04368f-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1020187-
Descrição: dc.descriptionHerein, we used thymine (HThy) as a ligand to form two new ruthenium(II) complexes with formula [Ru(PPh3)2(Thy)(bipy)]PF6 (1) and [Ru(Thy)(bipy)(dppb)]PF6 (2). The complexes were characterized by spectroscopic, spectrometric and X-ray crystallography analyses. Complexes 1 and 2 can interact with ctDNA presenting binding constants, Kb, of 0.4 and 1.2 × 103 M−1, respectively. Their cytotoxic activities towards tumor cell lines (B16-F10, HepG2, K562 and HL-60) and non-tumor cells (PBMCs) were evaluated using the Alamar blue assay. Complex 1 exhibits high cytotoxicity against tumor cells, showing IC50 values of 0.01 and 1.81 μM against the HL-60 and HepG2 cell lines, respectively. Therefore, compound 1 can be considered as a promising antitumor metallodrug.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleRu(II)–thyminate complexes : new metallodrug candidates against tumor cells.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.