Sustained kidney biochemical derangement in treated experimental diabetes : a clue to metabolic memory.

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Autor(es): dc.creatorOliveira, Antônio Anax Falcão de-
Autor(es): dc.creatorOliveira, Tiago Franco de-
Autor(es): dc.creatorBobadilla, Larissa Letícia-
Autor(es): dc.creatorGarcia, Camila Carrião Machado-
Autor(es): dc.creatorBerra, Carolina Maria-
Autor(es): dc.creatorPinto, Nadja Cristhina de Souza-
Autor(es): dc.creatorMedeiros, Marisa Helena Gennari de-
Autor(es): dc.creatorMascio, Paolo Di-
Autor(es): dc.creatorZatz, Roberto-
Autor(es): dc.creatorLoureiro, Ana Paula de Melo-
Data de aceite: dc.date.accessioned2025-08-21T15:37:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:37:28Z-
Data de envio: dc.date.issued2017-11-27-
Data de envio: dc.date.issued2017-11-27-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9183-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/srep40544-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1020021-
Descrição: dc.descriptionThe occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently changed after late glycemic control in streptozotocin-induced diabetic rats. This pathway comprises an early decline of uric acid clearance and pAMPK expression followed by fumarate accumulation, increased TGF-β expression, reduced PGC-1α expression, and downregulation of methylation and hydroxymethylation of mitochondrial DNA. The sustained decrease of uric acid clearance in treated diabetes may support the prolonged kidney biochemical alterations observed after tight glycemic control, and this regulation is likely mediated by the sustained decrease of AMPK activity and the induction of inflammation. This manuscript proposes the first consideration of the possible role of hyperuricemia and the underlying biochemical changes as part of metabolic memory in diabetic nephropathy development after glycemic control.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Fonte: o próprio artigo.-
Título: dc.titleSustained kidney biochemical derangement in treated experimental diabetes : a clue to metabolic memory.-
Aparece nas coleções:Repositório Institucional - UFOP

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