Formulations with microencapsulated Fe–peptides improve in vitro bioaccessibility and bioavailability.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorGaigher, Bruna-
Autor(es): dc.creatorSilva, Emanueli do Nascimento da-
Autor(es): dc.creatorSanches, Vitor Lacerda-
Autor(es): dc.creatorMilani, Raquel Fernanda-
Autor(es): dc.creatorGalland, Fabiana-
Autor(es): dc.creatorCadore, Solange-
Autor(es): dc.creatorGrancieri, Mariana-
Autor(es): dc.creatorPacheco, Maria Teresa Bertoldo-
Data de aceite: dc.date.accessioned2025-08-21T15:35:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:35:37Z-
Data de envio: dc.date.issued2023-05-19-
Data de envio: dc.date.issued2023-05-19-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16612-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.crfs.2022.03.007-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1019224-
Descrição: dc.descriptionThe bioaccessibility and the bioavailability of iron complexed to peptides (active) in microparticles forms con- tained in dry beverages formulations were evaluated. The peptide-iron complexes microparticles were obtained by spray drying and added in three dry formulations (tangerine, strawberry, and chocolate flavors). The peptides isolated by iron ion affinity (IMAC-Fe III) had their biological activity predicted by BIOPEP® database and were evaluated by molecular coupling. The bioaccessibility was evaluated by solubility and dialysability and the bioavalability was assessed by Caco-2 cellular model. The proportion 10:1 of peptide-iron complexes presented higher rates of bioaccessibility (49%) and bioavailability (56%). The microparticle with peptide-iron complex showed greater solubility after digestion (39.1%), bioaccessibility (19.8%), and bioavailability (34.8%) than the ferrous sulfate salt (control) for the three assays (10.2%; 12.9%; 9.7%, respectively). Tangerine and strawberry formulations contributed to the iron absorption according to the results of bioaccessibility (36.2%, 30.0% respectively) and bioavailability (80.5%, 84.1%, respectively). The results showed that iron peptide complexa- tion and microencapsulation process improve the bioaccessibility and bioavailability when incorporated into formulations.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectDialyzability-
Palavras-chave: dc.subjectMolecular coupling-
Título: dc.titleFormulations with microencapsulated Fe–peptides improve in vitro bioaccessibility and bioavailability.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.