Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMelo, Carolina Mirtes-
Autor(es): dc.creatorCardoso, Jéssica Ferreira-
Autor(es): dc.creatorPerasoli, Fernanda Barçante-
Autor(es): dc.creatorOliveira Neto, Ari Soares de-
Autor(es): dc.creatorPinto, Luccas Moreira-
Autor(es): dc.creatorMarques, Maria Betânia de Freitas-
Autor(es): dc.creatorMussel, Wagner da Nova-
Autor(es): dc.creatorMagalhães, Juliana Teixeira de-
Autor(es): dc.creatorMoura, Sandra Aparecida Lima de-
Autor(es): dc.creatorAraújo, Marcelo Gonzaga de Freitas-
Autor(es): dc.creatorSilva, Gisele Rodrigues da-
Data de aceite: dc.date.accessioned2025-08-21T15:35:26Z-
Data de disponibilização: dc.date.available2025-08-21T15:35:26Z-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12216-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0144861719312767-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.carbpol.2019.115608-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1019143-
Descrição: dc.descriptionThe treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Título: dc.titleAmphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis.-
Aparece nas coleções:Repositório Institucional - UFOP

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