Lifetime overproduction of circulating angiotensin‑(1‑7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Lenice Kappes Becker-
Autor(es): dc.creatorTotou, Nádia Lúcia-
Autor(es): dc.creatorOliveira, Mariana Flávia-
Autor(es): dc.creatorCoelho, Daniel Barbosa-
Autor(es): dc.creatorOliveira, Emerson Cruz de-
Autor(es): dc.creatorSantos, Daisy Motta-
Autor(es): dc.creatorGarcia, Emerson Silami-
Autor(es): dc.creatorSantos, Maria José Campagnole dos-
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Data de aceite: dc.date.accessioned2025-08-21T15:35:00Z-
Data de disponibilização: dc.date.available2025-08-21T15:35:00Z-
Data de envio: dc.date.issued2020-03-06-
Data de envio: dc.date.issued2020-03-06-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11965-
Fonte completa do material: dc.identifierhttps://doi.org/10.4103/CJP.CJP_57_19-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018928-
Descrição: dc.descriptionAngiotensin‑(1‑7) (Ang‑[1‑7]) can modulate glucose metabolism and protect against muscular damage. The aim of this study was to investigate the influence of lifetime increase of circulating levels of Ang‑(1‑7) at exhaustive swimming exercise (ESE). Sprague‑Dawley (SD) and transgenic rats TGR(A1‑7)3292 (TR) which overproduce Ang‑(1‑7) (2.5‑fold increase) were submitted to ESE. The data showed no differences in time to exhaustion (SD: 4.90 ± 1.37 h vs. TR: 5.15 ± 1.15 h), creatine kinase, and transforming growth factor beta (TGF-β). Lactate dehydrogenase (SD: 219.9 ± 12.04 U/L vs. TR: 143.9 ± 35.21 U/L) and α‑actinin (SD: 336.7 ± 104.5 U/L vs. TR: 224.6 ± 82.45 U/L) values were significantly lower in TR. There was a significant decrease in the range of blood glucose levels (SD: −41.4 ± 28.32 mg/dl vs. TR: −13.08 ± 39.63 mg/dl) in SD rats. Muscle (SD: 0.06 ± 0.02 mg/g vs. TR: 0.13 ± 0.01 mg/g) and hepatic glycogen (SD: 0.66 ± 0.36 mg/g vs. TG: 2.24 ± 1.85 mg/g) in TR were higher. The TR presented attenuation of the increase in skeletal muscle damage biomarkers and of the changes in glucose metabolism after ESE.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Fonte: o próprio artigo.-
Palavras-chave: dc.subjectGlucose metabolism-
Título: dc.titleLifetime overproduction of circulating angiotensin‑(1‑7) in rats attenuates the increase in skeletal muscle damage biomarkers after exhaustive exercise.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.