Repositioning of tamoxifen in surface-modified nanocapsules as a promising oral treatment for visceral leishmaniasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Débora Faria-
Autor(es): dc.creatorReis, Levi Eduardo Soares-
Autor(es): dc.creatorMachado, Marina Guimarães Carvalho-
Autor(es): dc.creatorDophine, Douglas Daniel-
Autor(es): dc.creatorAndrade, Vinicius Roberto de-
Autor(es): dc.creatorLima, Wanderson Geraldo de-
Autor(es): dc.creatorAndrade, Margareth Spangler-
Autor(es): dc.creatorVilela, José Mário Carneiro-
Autor(es): dc.creatorReis, Alexandre Barbosa-
Autor(es): dc.creatorLana, Gwenaelle Elza Nathalie Pound-
Autor(es): dc.creatorRezende, Simone Aparecida-
Autor(es): dc.creatorMosqueira, Vanessa Carla Furtado-
Data de aceite: dc.date.accessioned2025-08-21T15:34:15Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:15Z-
Data de envio: dc.date.issued2023-05-16-
Data de envio: dc.date.issued2023-05-16-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16570-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/pharmaceutics13071061-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018605-
Descrição: dc.descriptionStandards of care for human visceral leishmaniasis (VL) are based on drugs used parenter- ally, and oral treatment options are urgently needed. In the present study, a repurposing strategy was used associating tamoxifen (TMX) with polyethylene glycol-block-polylactide nanocapsules (NC) and its anti-leishmanial efficacy was reported in vivo. Stable surface modified-NC (5 mg/mL of TMX) exhibited 200 nm in size, +42 mV of zeta potential, and 98% encapsulation efficiency. Atomic force microscopy evidenced core-shell-NC. Treatment with TMX-NC reduced parasite-DNA quantified in liver and spleen compared to free-TMX; and provided a similar reduction of parasite burden compared with meglumine antimoniate in mice and hamster models. Image-guided biodistribution showed accumulation of NC in liver and spleen after 30 min post-administration. TMX-NC reduced the number of liver granulomas and restored the aspect of capsules and trabeculae in the spleen of infected animals. TMX-NC was tested for the first time against VL models, indicating a promising formulation for oral treatment.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectDrug release-
Palavras-chave: dc.subjectRepurposing-
Palavras-chave: dc.subjectEfficacy-
Palavras-chave: dc.subjectPhysicochemical characterization-
Título: dc.titleRepositioning of tamoxifen in surface-modified nanocapsules as a promising oral treatment for visceral leishmaniasis.-
Aparece nas coleções:Repositório Institucional - UFOP

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