Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLopes, Ana Cristina dos Santos-
Autor(es): dc.creatorPerucci, Luiza Oliveira-
Autor(es): dc.creatorEvangelista, Fernanda Cristina Gontijo-
Autor(es): dc.creatorGodoi, Lara Carvalho-
Autor(es): dc.creatorSabino, Adriano de Paula-
Autor(es): dc.creatorGomes, Karina Braga-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorDusse, Luci Maria Sant'Ana-
Autor(es): dc.creatorAlpoim, Patrícia Nessralla-
Data de aceite: dc.date.accessioned2025-08-21T15:34:08Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:08Z-
Data de envio: dc.date.issued2020-03-10-
Data de envio: dc.date.issued2020-03-10-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11972-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihub-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.mcp.2019.04.004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018562-
Descrição: dc.descriptionBackground: Genetic, immune and environmental factors are involved in preeclampsia (PE) etiopathogenesis. Considering that hypertension and poor placental perfusion are important features in PE, polymorphisms in the angiotensin-converting enzyme (ACE) and estrogen nuclear receptor 1 (ESR1) genes could be involved in the predisposition and/or development of the disease. The aim of this study was to evaluate if polymorphisms in ACE and ESR1 genes were associated with PE occurrence. Material and Methods: This case-control study included 209 Brazilian pregnant women (107 with severe PE and 102 normotensive controls). The polymorphisms were investigated by polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Results: No significant difference between PE versus normotensive pregnant women, as well as early versus late PE, was observed when compared the allelic and genotypic frequencies of insertion/deletion polymorphism in intron 16 of the ACE gene and the single nucleotide polymorphisms (SNPs - rs2234693 and rs9340799) of the ESR1 gene. Conclusion: This pioneer study involving Brazilian women showed no association among the studied polymorphisms and PE, which suggests that ins/del ACE and SNPs ESR1 do not contribute to this disease occurrence in Brazil.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectHypertension-
Título: dc.titleAssociation among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women.-
Aparece nas coleções:Repositório Institucional - UFOP

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