Antibacterial screening of plants from the Brazilian Atlantic Forest led to the identification of active compounds in Miconia latecrenata (DC.) Naudin.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorRodrigues, Laís Azevedo-
Autor(es): dc.creatorAlmeida, Ayla das Chagas-
Autor(es): dc.creatorGontijo, Douglas da Costa-
Autor(es): dc.creatorSalustiano, Iorrana Vieira-
Autor(es): dc.creatorAlmeida, Alisson Andrade-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Autor(es): dc.creatorRibon, Andrea de Oliveira Barros-
Autor(es): dc.creatorLeite, João Paulo Viana-
Data de aceite: dc.date.accessioned2025-08-21T15:34:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:02Z-
Data de envio: dc.date.issued2021-12-05-
Data de envio: dc.date.issued2021-12-05-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14094-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1802271-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/14786419.2020.1802271-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018524-
Descrição: dc.descriptionAntibiotic resistance is a serious global threat to public health. This has promoted the research for new drug targets, and the use of other approaches, such as antimicrobial combined therapy. The present study evaluated the antibacterial activity of 88 extracts from Brazilian Atlantic Forest trees. The organic extract from leaves of Miconia latecrenata (EMl) was the most promising for inhibiting the growth of Staphylococcus aureus (0.3 mg/mL) and Pseudomonas aeruginosa (2.5 mg/mL). After the bioguided frac tionation of EMl and metabolite profiling performed by UPLC DAD-MS/MS, the ethyl acetate (AFMl) and aqueous (WFMl) frac tions showed a mixture of phenolic compounds derived from ellagic acid and quercetin. The MIC value of AFMl was two-times lower than EMl for P. aeruginosa, suggesting that these phenolic compounds can perform bioactivity. Furthermore, EMI and AFMl showed synergism with ampicillin and tetracycline for S. aureus and P. aeruginosa, respectively. These findings suggest that extract and fractions of the Miconia latecrenata leaves can be used as therapeutic antibacterial agents.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectBioprospection-
Palavras-chave: dc.subjectHydrolyz able tannins-
Palavras-chave: dc.subjectPhenolic compounds-
Título: dc.titleAntibacterial screening of plants from the Brazilian Atlantic Forest led to the identification of active compounds in Miconia latecrenata (DC.) Naudin.-
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