Oral Ang-(1-7) treatment improves white adipose tissue remodeling and hypertension in rats with metabolic syndrome.

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Autor(es): dc.creatorBarbosa, Maria Andréa-
Autor(es): dc.creatorSousa, Graziele Galdino de-
Autor(es): dc.creatorCastro, Uberdan Guilherme Mendes de-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorFigueiredo, Vivian Paulino-
Autor(es): dc.creatorCota, Renata Guerra de Sá-
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Autor(es): dc.creatorAlzamora, Andréia Carvalho-
Data de aceite: dc.date.accessioned2025-08-21T15:33:40Z-
Data de disponibilização: dc.date.available2025-08-21T15:33:40Z-
Data de envio: dc.date.issued2020-03-13-
Data de envio: dc.date.issued2020-03-13-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/11991-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.nutx.2019.100004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018352-
Descrição: dc.descriptionObjective: Angiotensin (Ang)-(1-7) has preventive effects on metabolic syndrome (MetS). The aim of this study was to evaluate the therapeutic effect of oral Ang-(1-7) on mean arterial pressure (MAP), insulin resistance (IR), inflammatory process, and remodeling of white adipose tissue (WAT) in rats with establishedMetS. Methods: Rats were subjected to control (CT; AIN-93M) or high-fat (HF) diets for 13 wk to induce MetS and treated with Ang-(1-7) or vehicle (V) for the last 6 wk. At the end of 13 wk, MAP, biochemical and histological parameters, and uncoupling protein (UCP) and inflammatory gene expression were determined by quantitative reverse transcription polymerase chain reaction. Results: HF-V rats showed increased visceral fat deposition, inflammatory cytokine expression, hyperplasia, and hypertrophy in retroperitoneal (WAT) and brown adipose tissue (BAT). Additionally, the gastrocnemius muscle reduced UCP-3 and increased the UCP-1 expression in BAT. HF-V also elevated levels of plasma insulin, glucose, homeostatic model assessment (HOMA) of IR and HOMA-b, and increased body mass, adiposity, and MAP. Ang-(1-7) treatment in rats with MetS [HF-Ang-(1-7)] reduced WAT area, number of adipocytes, and expression of proinflammatory adipokines in WAT and BAT and increased UCP-3 in gastrocnemius muscle and UCP-1 expression in BAT compared with the HF-V group. These events prevented body mass gain, reduced adiposity, and normalized fasting plasma glucose, insulin levels, HOMA-IR, HOMA-b, and MAP. Conclusion: Data from the present study demonstrated that oral Ang-(1-7) treatment is effective in restoring biochemical parameters and hypertension in established MetS by improving hypertrophy and hyperplasia in WAT and inflammation in adipose tissue, and regulating metabolic processes in the gastrocnemius muscle and BAT.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Fonte: o próprio artigo.-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectBrown adipose tissue-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectHigh-fat diet-
Título: dc.titleOral Ang-(1-7) treatment improves white adipose tissue remodeling and hypertension in rats with metabolic syndrome.-
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