Morphometric evaluation and nonclassical criteria for the diagnosis of HPV infection and cytological atypia in cervical samples. 

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Autor(es): dc.creatorSana, Dandara Emery Morais-
Autor(es): dc.creatorMiranda, Priscila Mayrink de-
Autor(es): dc.creatorPitol, Bruna Caroline Vieira-
Autor(es): dc.creatorSilva, Nayara Nascimento Toledo-
Autor(es): dc.creatorSilva, Ismael Dale Cotrim Guerreiro da-
Autor(es): dc.creatorStocco, Rita de Cássia-
Autor(es): dc.creatorBeçak, Willy-
Autor(es): dc.creatorLima, Angélica Alves-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Data de aceite: dc.date.accessioned2025-08-21T15:33:14Z-
Data de disponibilização: dc.date.available2025-08-21T15:33:14Z-
Data de envio: dc.date.issued2017-02-23-
Data de envio: dc.date.issued2017-02-23-
Data de envio: dc.date.issued2013-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7307-
Fonte completa do material: dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/dc.22955/abstract;jsessionid=F9558148044C5AD060CD7291C46D88E8.f04t04-
Fonte completa do material: dc.identifierhttps://doi.org/10.1002/dc.22955-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018160-
Descrição: dc.descriptionHerein, we evaluated cervical samples from normal tissue or HPV-infected tissue, to determine if the relative nuclear/cytoplasmic ratio (NA/CA) and the presence of nonclassical cytological criteria are a novel cytological criterion for the diagnosis of HPV. Significantly, larger NA/CA ratios were found for the HPV−ATYPIA+ and HPV+ATYPIA+ groups compared with HPV−ATYPIA− group, regardless of collection method. For the samples collected with a spatula, only three samples from the HPV−ATIPIA− group showed four or more nonclassical parameters (i.e., were positive), while a larger number of the samples in the HPV−ATYPIA+, HPV+ATYPIA−, and HPV+ATYPIA+ groups were positive (13, 4, and 13 samples, respectively). Among those collected with a brush, no sample showed four or more nonclassical criteria in the HPV−ATYPIA− group, while a number of samples were positive in the HPV−ATYPIA+, HPV+ATYPIA−, and HPV+ATYPIA+ groups (4, 3, and 4 samples, respectively). HPV infection was associated with significant morphometrical changes; no increase in the NA/CA ratio was found in the HPV+ATYPIA- samples, compared with the HPV−ATIPIA− samples collected with either a spatula or a brush. In conclusion, by including nonclassical cytological criteria into the patient diagnosis, we were able to reduce the number of false negative and false positive HPV diagnoses made using conventional cytology alone. Diagn. Cytopathol.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectCervix-vaginal cytology-
Palavras-chave: dc.subjectMorphometry-
Palavras-chave: dc.subjectMolecular biology-
Título: dc.titleMorphometric evaluation and nonclassical criteria for the diagnosis of HPV infection and cytological atypia in cervical samples. -
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