Psychotria viridis : chemical constituents from leaves and biological properties.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSoares, Débora Barbosa da Silva-
Autor(es): dc.creatorDuarte, Lucienir Pains-
Autor(es): dc.creatorCavalcanti, André Dias-
Autor(es): dc.creatorSilva, Fernando César-
Autor(es): dc.creatorBraga, Ariadne Duarte-
Autor(es): dc.creatorLopes, Miriam Teresa Paz-
Autor(es): dc.creatorTakahashi, Jacqueline Aparecida-
Autor(es): dc.creatorVieira Filho, Sidney Augusto-
Data de aceite: dc.date.accessioned2025-08-21T15:32:56Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:56Z-
Data de envio: dc.date.issued2017-08-31-
Data de envio: dc.date.issued2017-08-31-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/8637-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1018025-
Descrição: dc.descriptionThe phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsOs trabalhos publicados no periódico Anais da Academia Brasileira de Ciências, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Anais da Academia Brasileira de Ciências <http://www.scielo.br/scielo.php?script=sci_serial&pid=0001-3765&lng=en&nrm=iso>. Acesso em: 23 jan. 2020.-
Palavras-chave: dc.subjectRubiaceae-
Título: dc.titlePsychotria viridis : chemical constituents from leaves and biological properties.-
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