Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBenedicto, Augusto Vieira Lima-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorGraminha, Angelica Ellen-
Autor(es): dc.creatorKuznetsov, Aleksey Evgenyevich-
Autor(es): dc.creatorEllena, Javier Alcides-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorLeite, Clarice Queico Fujimura-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:32:19Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:19Z-
Data de envio: dc.date.issued2016-11-07-
Data de envio: dc.date.issued2016-11-07-
Data de envio: dc.date.issued2016-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7066-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.5935/0103-5053.20150237-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1017758-
Descrição: dc.descriptionThe [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1’-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsTodo o conteúdo do periódico Journal of the Brazilian Chemical Society, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Journal of the Brazilian Chemical Society <http://www.scielo.br/scielo.php?script=sci_serial&pid=0103-5053&lng=en&nrm=iso>. Acesso em: 23 ago. 2019.-
Palavras-chave: dc.subjectRuthenium complexes-
Palavras-chave: dc.subjectPyrimidine-2-thiolate-
Palavras-chave: dc.subjectDiphosphine ligand-
Palavras-chave: dc.subjectCytotoxity - tuberculosis-
Título: dc.titleAnti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.-
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