Imines and lactones derived from friedelanes and their cytotoxic activity.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorAguilar, Mariana Guerra de-
Autor(es): dc.creatorSousa, Grasiely Faria de-
Autor(es): dc.creatorEvangelista, Fernanda Cristina Gontijo-
Autor(es): dc.creatorSabino, Adriano de Paula-
Autor(es): dc.creatorVieira Filho, Sidney Augusto-
Autor(es): dc.creatorDuarte, Lucienir Pains-
Data de aceite: dc.date.accessioned2025-08-21T15:32:11Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:11Z-
Data de envio: dc.date.issued2022-12-06-
Data de envio: dc.date.issued2022-12-06-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/15871-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/full/10.1080/14786419.2018.1508137-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/14786419.2018.1508137-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1017702-
Descrição: dc.descriptionFriedelan-3-one (1) and friedelane-3,16-dione (2) isolated from leaves and branches of Maytenus robusta Reissek were subjected to structural modifications via nucleophilic addition to the carbonyl group and Baeyer-Villiger oxidation in order to synthesize potential cytotoxic compounds. The oximes friedelane-3-hydroxyimino (3) and 3-hydroxyiminofriedelan-16-one (4) together with the lactones friedelane-3,4-lactone (5) and 3,4-lactonefriedelan-16-one (6) were characterized by IR and NMR spectroscopic analyses. Compounds 4 and 6 are reported for the first time. Cytotoxic screening via MTT assay in human leukemia cell lines (THP-1 and K562) demonstrated no significant improvement of compounds 3-6 when compared to the starting materials. Only compounds 3 and 5 demonstrated an improvement against K562 cells. However, the same assay on ovar- ian and breast cancer cell lines (TOV-21G and MDA-MB-231) showed a reduction in the IC50 for compounds 4-6, indicating that ring A modifications may enhance the biological potential.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectPentacyclic triterpenes-
Palavras-chave: dc.subjectFriedelane derivatives-
Palavras-chave: dc.subjectCytotoxicity property-
Palavras-chave: dc.subjectTHP-1 cell line-
Palavras-chave: dc.subjectK562 cell line-
Título: dc.titleImines and lactones derived from friedelanes and their cytotoxic activity.-
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