Anti-Trypanosoma cruzi potential of vestitol isolated from lyophilized red propolis.

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Autor(es): dc.creatorSousa, Lucas Resende Dutra-
Autor(es): dc.creatorAmparo, Tatiane Roquete-
Autor(es): dc.creatorSouza, Gustavo Henrique Bianco de-
Autor(es): dc.creatorFerraz, Aline Tonhela-
Autor(es): dc.creatorFonseca, Kátia da Silva-
Autor(es): dc.creatorAzevedo, Amanda Scofield de-
Autor(es): dc.creatorNascimento, Andréa Mendes do-
Autor(es): dc.creatorAndrade, Ângela Leão-
Autor(es): dc.creatorSeibert, Janaína Brandão-
Autor(es): dc.creatorValverde, Thalita Marcolan-
Autor(es): dc.creatorBraga, Saulo Fehelberg Pinto-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorSantos, Viviane Martins Rebello dos-
Data de aceite: dc.date.accessioned2025-08-21T15:31:17Z-
Data de disponibilização: dc.date.available2025-08-21T15:31:17Z-
Data de envio: dc.date.issued2025-01-29-
Data de envio: dc.date.issued2025-01-29-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19656-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/molecules28237812-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1017309-
Descrição: dc.descriptionChagas disease (CD) is a worldwide public health problem, and the drugs available for its treatment have severe limitations. Red propolis is a natural extract known for its high content of phenolic compounds and for having activity against T. cruzi. The aim of this study was to investigate the trypanocidal potential of red propolis to isolate, identify, and indicate the mode of action of the bioactive compounds. The results revealed that the total phenolic content was 15.4 mg GAE/g, and flavonoids were 7.2 mg QE/g. The extract was fractionated through liquid–liquid partitioning, and the trypanocidal potential of the samples was evaluated using the epimastigote forms of the Y strain of T. cruzi. In this process, one compound was characterized by MS, 1H, and 13C NMR and identified as vestitol. Cytotoxicity was evaluated employing MRC-5 fibroblasts and H9C2 cardiomyocytes, showing cytotoxic concentrations above 15.62 µg/mL and 31.25 µg/mL, respectively. In silico analyses were applied, and the data suggested that the substance had a membrane-permeation-enhancing effect, which was confirmed through an in vitro assay. Finally, a molecular docking analysis revealed a higher affinity of vestitol with farnesyl diphosphate synthase (FPPS). The identified isoflavan appears to be a promising lead compound for further development to treat Chagas disease.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectIsolation-
Palavras-chave: dc.subjectMembrane permeability-
Título: dc.titleAnti-Trypanosoma cruzi potential of vestitol isolated from lyophilized red propolis.-
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