Functional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBotoni, Fernando Antônio-
Autor(es): dc.creatorLambertucci, José Roberto-
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Autor(es): dc.creatorMüller, Johannes-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Autor(es): dc.creatorWallukat, Gerd-
Data de aceite: dc.date.accessioned2025-08-21T15:31:03Z-
Data de disponibilização: dc.date.available2025-08-21T15:31:03Z-
Data de envio: dc.date.issued2025-02-21-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19779-
Fonte completa do material: dc.identifierhttps://doi.org/10.3389/fimmu.2024.1404384-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1017210-
Descrição: dc.descriptionIntroduction: Schistosomiasis (SM) is a parasitic disease caused by Schistosoma mansoni. SM causes chronic inflammation induced by parasitic eggs, with collagen/fibrosis deposition in the granuloma process in the liver, spleen, central nervous system, kidneys, and lungs. Pulmonary arterial hypertension (PAH) is a clinical manifestation characterized by high pressure in the pulmonary circulation and right ventricular overload. This study investigated the production of functional autoantibodies (fAABs) against the second loop of the G-protein-coupled receptor (GPCR) in the presence of hepatic and PAH forms of human SM. Methods: Uninfected and infected individuals presenting acute and chronic manifestations (e.g., hepatointestinal, hepato-splenic without PAH, and hepato-splenic with PAH) of SM were clinically evaluated and their blood was collected to identify fAABs/GPCRs capable of recognizing endothelin 1, angiotensin II, and a-1 adrenergic receptor. Human serum was analyzed in rat cardiomyocytes cultured in the presence of the receptor antagonists urapidil, losartan, and BQ123. Results: The fAABs/GPCRs from chronic hepatic and PAH SM individuals, but not from acute SM individuals, recognized the three receptors. In the presence of the antagonists, there was a reduction in beating rate changes in cultured cardiomyocytes. In addition, binding sites on the extracellular domain functionality of fAABs were identified, and IgG1 and/or IgG3 antibodies were found to be related to fAABs. Conclusion: Our data suggest that fAABs against GPCR play an essential role in vascular activity in chronic SM (hepatic and PAH) and might be involved in the development of hypertensive forms of SM.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited. Fonte: PDF do artigo.-
Palavras-chave: dc.subjectSchistosoma mansoni-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPulmonary hypertension-
Título: dc.titleFunctional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis.-
Aparece nas coleções:Repositório Institucional - UFOP

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