"Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAraujo Neto, João Honorato de-
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorLeite, Celisnolia Morais-
Autor(es): dc.creatorColina Vegas, Legna Andreina-
Autor(es): dc.creatorNóbrega, Joaquim de Araújo-
Autor(es): dc.creatorCastellano, Eduardo Ernesto-
Autor(es): dc.creatorEllena, Javier Alcides-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:30:38Z-
Data de disponibilização: dc.date.available2025-08-21T15:30:38Z-
Data de envio: dc.date.issued2021-12-15-
Data de envio: dc.date.issued2021-12-15-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14247-
Fonte completa do material: dc.identifierhttps://doi.org/10.21577/0103-5053.20200076-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1017045-
Descrição: dc.descriptionMononuclear and binuclear RuII/arene/triphenylphosphine complexes with p-substituted benzoic acid derivatives were prepared and characterized. These monocationic complexes of type [Ru(η6 -p-cymene)(PPh3)L] (L = benzoic acid (1), p-hydroxybenzoic acid (2), p-nitrobenzoic acid (3) and terephthalic acid (4)) were characterized using various techniques, such as nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry, and the crystal structure of 1, 3 and 4 were determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated, in vitro, against tumorigenic [MDA-MB-231, MCF-7 (breast), A549 (lung) and DU-145 (prostate)] and non-tumorigenic [MCF-10A (breast), MRC-5 (lung) and PNT-2 (prostate)] cells. The binuclear complex (4) was inactive due to its low solubility. Complexes 1, 2 and 3 showed similar cytotoxicity, however, complex 1 presented better selectivity index against MDA-MB-231 than compounds 2 and 3. Cellular ruthenium absorption was explored by inductively coupled plasma mass spectrometry (ICP-MS) analyzing the whole cells and the culture medium. Complementary studies showed that complex 1 inhibited colony formation, induced morphology changes in cells and promoted cell cycle arrest in the Sub-G1 phase for the MDA-MB-231 cells.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.-
Palavras-chave: dc.subjectPiano-stool RuII complexes-
Palavras-chave: dc.subjectBenzoic acid analogs-
Palavras-chave: dc.subjectCellular uptake-
Título: dc.title"Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids.-
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