New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorGraminha, Angelica Ellen-
Autor(es): dc.creatorPopolin, Cecília-
Autor(es): dc.creatorAraujo Neto, João Honorato de-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorGodoy, Luani Rezende-
Autor(es): dc.creatorColina Vegas, Legna Andreina-
Autor(es): dc.creatorEllena, Javier Alcides-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Autor(es): dc.creatorCominetti, Márcia Regina-
Data de aceite: dc.date.accessioned2025-08-21T15:30:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:30:28Z-
Data de envio: dc.date.issued2023-11-23-
Data de envio: dc.date.issued2023-11-23-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17870-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0223523422006742-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.ejmech.2022.114772-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1016967-
Descrição: dc.descriptionIn this work we present the synthesis and characterization of six new ruthenium compounds with general formulae [Ru(L)(dppb)(bipy)]PF6 and [Ru(L)(dppe)2]PF6 where L = salicylic acid (Sal), 4-aminosalicylic acid (AmSal) or 2,4-dihydroxybenzoic acid (DiSal), dppb = 1,4-bis(diphenylphosphino)butane, dppe = 1,2-bis (diphenylphosphino)ethane and bipy = 2,2′ -bipyridine. The complexes were characterized by elemental analysis, molar conductivity, cyclic voltammetry, NMR, UV–vis and IR spectroscopies, and two by X-ray crystallography. The 31P{1 H} NMR spectra of the complexes with the general formula [Ru(L)(dppe)2]PF6 showed that the phosphorus signals are solvent-dependent. Aprotic solvents, which form strong hydrogen bonds with the complexes, inhibit the free rotation of the salicylic acid-based, modifying the diphosphine cone angles, leading to distortion of the phosphorus signals in the NMR spectra. The cytotoxicity of the complexes was evaluated in MCF7, MDA-MB-231, SKBR3 human breast tumor cells, and MCF-10 non-tumor cell lines. The complexes with the structural formula [Ru(L)(dppe)2]PF6 were the most cytotoxic, and the complex [Ru(AmSal)(dppe)2]PF6 with L = 4-aminosalicylic acid ligand was the most selective for the MDA-MB-231 cell line. This complex interacts with the transferrin and induces apoptosis through the intrinsic pathway, as demonstrated by increased levels of proteins involved in apoptotic cell death.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectRuthenium complexes-
Palavras-chave: dc.subjectSalicylic acids-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectCell death-
Título: dc.titleNew ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.-
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