The role of IL‐10 in immune responses against Pseudomonas aeruginosa during acute lung infection.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBelo, Valéria Aparecida-
Autor(es): dc.creatorPereira, Jéssica Assis-
Autor(es): dc.creatorSouza, Sara Franchin Duarte de-
Autor(es): dc.creatorTana, Fernanda de Lima-
Autor(es): dc.creatorPereira, Bruna Pinheiro-
Autor(es): dc.creatorLopes, Débora de Oliveira-
Autor(es): dc.creatorCeron, Carla Speroni-
Autor(es): dc.creatorNovaes, Rômulo Dias-
Autor(es): dc.creatorCorsetti, Patrícia Paiva-
Autor(es): dc.creatorAlmeida, Leonardo Augusto de-
Data de aceite: dc.date.accessioned2025-08-21T15:30:19Z-
Data de disponibilização: dc.date.available2025-08-21T15:30:19Z-
Data de envio: dc.date.issued2023-03-23-
Data de envio: dc.date.issued2023-03-23-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16419-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007/s00441-020-03308-4#:~:text=Despite%20the%20onset%20of%20the,Apidianakis%202013%3B%20Hazlett%20et%20al-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s00441-020-03308-4-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1016903-
Descrição: dc.descriptionPseudomonas aeruginosa is considered an opportunistic pathogen of great clinical importance. The clearance of this bac- terium occurs through recognition of the pathogen by innate immune system receptors, leading to a lung infammatory response. However, this response must be controlled via immunoregulatory pathways. In this study, we evaluate the role of endogenous murine IL-10 after acute infection with the virulent strain P. aeruginosa PA14. To assess the role of IL-10, intratracheal infection with the PA14 strain was performed in C57BL/6 or IL-10 KO mice. The PA14 strain was recovered in both types of animals, although IL-10 KO mice presented a higher number of viable bacteria in the lung when compared to the C57BL/6 group. Histopathological and stereological analyses showed that IL-10 KO mice had higher tissue damage and infammatory infltrate when compared to control animals. The activity of MMP-9 but not MMP-2, as well as IL-6 and TNF-α expression, were augmented in the lungs of infected animals and was much more evident in IL-10 KO animals when compared to the other analyzed groups. This work indicates that endogenous IL-10 control P. aeruginosa infection, the expression of pro-infammatory genes, MMP-9 activity and histopathological processes of the infectious process in question.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectImmunoregulation-
Palavras-chave: dc.subjectInterleukin-10-
Palavras-chave: dc.subjectLung infection-
Palavras-chave: dc.subjectInfammatory response-
Título: dc.titleThe role of IL‐10 in immune responses against Pseudomonas aeruginosa during acute lung infection.-
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