Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes.

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Autor(es): dc.creatorGomes, Matheus de Souza-
Autor(es): dc.creatorDonoghue, Mark T. A.-
Autor(es): dc.creatorMuniyappa, Mohan Kumar-
Autor(es): dc.creatorPereira, Roberta Verciano-
Autor(es): dc.creatorCota, Renata Guerra de Sá-
Autor(es): dc.creatorSpillane, Charles-
Data de aceite: dc.date.accessioned2025-08-21T15:29:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:28Z-
Data de envio: dc.date.issued2017-06-22-
Data de envio: dc.date.issued2017-06-22-
Data de envio: dc.date.issued2013-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/8049-
Fonte completa do material: dc.identifierhttps://link.springer.com/article/10.1007%2Fs00239-013-9563-2-
Fonte completa do material: dc.identifierhttps://doi.org/10.1007/s00239-013-9563-2-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1016547-
Descrição: dc.descriptionMicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into *20–24 nt molecules that can regulate the gene expression posttranscriptionally. MiRNA gene clusters have been identified in a range of species, where in miRNAs are often processed from polycistronic transcripts. In this study, a computational approach is used to investigate the extent of evolutionary conservation of the miR-71/2 cluster in animals, and to identify novel miRNAs in the miRNA cluster miR-71/2. The miR-71/2 cluster, consisting of copies of the miR-71 and miR-2 (including miR-13) families, was found to be Protostome-specific. Although, this cluster is highly conserved across the Protostomia, the miR-2 family is completely absent from the Deuterostomia species, while miR-71 is absent from the Vertebrata and Urochordata. The evolutionary conservation and clustering propensity of the miR-71/2 family across the Protostomes could indicate the common functional roles across the member species of the Protostomia.-
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Idioma: dc.languageen-
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Título: dc.titleComputational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes.-
Aparece nas coleções:Repositório Institucional - UFOP

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