Expression of SmATPDases 1 and 2 in Schistosoma mansoni eggs favours IL-10 production in infected individuals.

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Autor(es): dc.creatorGomides, Thalisson Artur Ribeiro-
Autor(es): dc.creatorSouza, Márcio Luís Moreira de-
Autor(es): dc.creatorFigueiredo, Amanda Braga de-
Autor(es): dc.creatorLima, Marlucy Rodrigues-
Autor(es): dc.creatorSilveira, Alda Maria Soares-
Autor(es): dc.creatorAssis, Girley Francisco Machado de-
Autor(es): dc.creatorFraga, Lúcia Alves Oliveira-
Autor(es): dc.creatorNunes, Gabriela Silveira-
Autor(es): dc.creatorMartucci, Letícia-
Autor(es): dc.creatorGarcia, Jennifer Delgado-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Autor(es): dc.creatorCarvalho, Andréa Teixeira de-
Autor(es): dc.creatorLeite, Pauline Martins-
Data de aceite: dc.date.accessioned2025-08-21T15:29:23Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:23Z-
Data de envio: dc.date.issued2025-03-25-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/20039-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1111/pim.13017-
Fonte completa do material: dc.identifierhttps://doi.org/10.1111/pim.13017-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1016506-
Descrição: dc.descriptionA role of IL-10 is down-regulating T-cell responses to schistosome antigens. Since SmATPDases can be correlated to modulation of the immune response, we evaluated the expression of enzymes in S. mansoni eggs. Faecal samples were collected from 40 infected individuals to detect coding regions of the SmATPDases. The cytokines were measured in supernatants of PBMC. The analysis was performed by the global median determination and set up high producers (HP) of cytokines. Six individuals expressed SmATPDase1, six expressed SmATPDase2 and six expressed both enzymes. The group who expressed only SmATPDase1 showedahighfrequencyofIFN-γ,TNFIL-4HP; individuals who expressed only SmATPDase2 showed a high frequency of IFN-γ, IL-6and IL-4 HP; and individuals who expressed bothenzymesshowedahighfrequencyofIL-10 HP. The comparison of the IFN-γ/IL-10 ratio presented higher indices in the group who had SmATPDase 2 expression than those who had the expression of both enzymes. The positive correlation between infection intensity and IL-10 levels remained only in the positive SmATPDase group. The IL-10 is the only cytokine induced by the expression of both enzymes. Our data suggest that the expression of both enzymes seems to be a fac tor that modulates the host immune response by inducing high IL-10 production.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectImmunomodulation-
Palavras-chave: dc.subjectSchistosomiasis-
Palavras-chave: dc.subjectSmATPDases-
Título: dc.titleExpression of SmATPDases 1 and 2 in Schistosoma mansoni eggs favours IL-10 production in infected individuals.-
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