Evaluation of anti-candida albicans activity and release of ketoconazole in PMMA-G-PEG 4000 films.

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Autor(es): dc.creatorReynaldo, Juliana Ribeiro-
Autor(es): dc.creatorNovack, Kátia Monteiro-
Autor(es): dc.creatorSousa, Lucas Resende Dutra-
Autor(es): dc.creatorVieira, Paula Melo de Abreu-
Autor(es): dc.creatorAmparo, Tatiane Roquete-
Autor(es): dc.creatorSouza, Gustavo Henrique Bianco de-
Autor(es): dc.creatorTeixeira, Luiz Fernando de Medeiros-
Autor(es): dc.creatorBarboza, Ana Paula Moreira-
Autor(es): dc.creatorNeves, Bernardo Ruegger Almeida-
Autor(es): dc.creatorAlvarenga, Meiry Edivirges-
Autor(es): dc.creatorMartins, Felipe Terra-
Autor(es): dc.creatorSantos, Viviane Martins Rebello dos-
Data de aceite: dc.date.accessioned2025-08-21T15:29:00Z-
Data de disponibilização: dc.date.available2025-08-21T15:29:00Z-
Data de envio: dc.date.issued2023-08-17-
Data de envio: dc.date.issued2023-08-17-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17230-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/ijms231810775-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1016316-
Descrição: dc.descriptionModified release systems depend on the selection of an appropriate agent capable of controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000) is commonly employed in drug release formulations while polymethyl methacrylate (PMMA) is non-toxic and has a good solubility in organic solvents. This study aimed at the incorporation of ketoconazole in PMMA-g-PEG 4000 and its derivatives, thus evaluating its release profile and anti-Candida albicans and cytotoxic activities. Ketoconazole was characterized and incorporated into the copolymers. The ketoconazole incorporated in the copolymer and its derivatives showed an immediate release profile. All copolymers with ketoconazole showed activity against Candida albicans and were non-toxic to human cells in the entire concentration tested.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Título: dc.titleEvaluation of anti-candida albicans activity and release of ketoconazole in PMMA-G-PEG 4000 films.-
Aparece nas coleções:Repositório Institucional - UFOP

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