Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorPereira, Isabela Amorim Gonçalves-
Autor(es): dc.creatorMendonça, Débora Vasconcelos Costa-
Autor(es): dc.creatorTavares, Grasiele de Sousa Vieira-
Autor(es): dc.creatorLage, Daniela Pagliara-
Autor(es): dc.creatorRamos, Fernanda Fonseca-
Autor(es): dc.creatorSilva, João Augusto Oliveira da-
Autor(es): dc.creatorAntinarelli, Luciana Maria Ribeiro-
Autor(es): dc.creatorMachado, Amanda Sanchez-
Autor(es): dc.creatorCarvalho, Lívia Mendes-
Autor(es): dc.creatorCarvalho, Ana Maria Ravena Severino-
Autor(es): dc.creatorSalustiano, Iorrana Vieira-
Autor(es): dc.creatorReis, Thiago Alves Rosa dos-
Autor(es): dc.creatorBandeira, Raquel Soares-
Autor(es): dc.creatorSilva, Alessandra M.-
Autor(es): dc.creatorMartins, Vivian Tamietti-
Autor(es): dc.creatorChávez Fumagalli, Miguel Angel-
Autor(es): dc.creatorHumbert, Maria Victoria-
Autor(es): dc.creatorRoatt, Bruno Mendes-
Autor(es): dc.creatorDuarte, Mariana Costa-
Autor(es): dc.creatorSouza, Daniel Menezes-
Autor(es): dc.creatorCoimbra, Elaine Soares-
Autor(es): dc.creatorLeite, João Paulo Viana-
Autor(es): dc.creatorCoelho, Eduardo Antônio Ferraz-
Autor(es): dc.creatorGonçalves, Denise Utsch-
Data de aceite: dc.date.accessioned2025-08-21T15:27:59Z-
Data de disponibilização: dc.date.available2025-08-21T15:27:59Z-
Data de envio: dc.date.issued2021-09-30-
Data de envio: dc.date.issued2021-09-30-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/13830-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12784-
Fonte completa do material: dc.identifierhttps://doi.org/10.1111/pim.12784-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1015770-
Descrição: dc.descriptionAims: Treatment for visceral leishmaniasis (VL) is hampered by the toxicity and/or high cost of drugs, as well as by emergence of parasite resistance. Therefore, there is an urgent need for new antileishmanial agents. Methods and Results: In this study, the antileishmanial activity of a diprenylated flavonoid called 5,7,3,4’-tetrahydroxy-6,8-diprenylisoflavone (CMt) was tested against Leishmania infantum and L amazonensis species. Results showed that CMt presented selectivity index (SI) of 70.0 and 165.0 against L infantum and L amazonensis promastigotes, respectively, and of 181.9 and 397.8 against respective axenic amastigotes. Amphotericin B (AmpB) showed lower SI values of 9.1 and 11.1 against L infantum and L amazonensis promastigotes, respectively, and of 12.5 and 14.3 against amastigotes, respectively. CMt was effective in the treatment of infected macrophages and caused alterations in the parasite mitochondria. L infantum-infected mice treated with miltefosine, CMt alone or incorporated in polymeric micelles (CMt/Mic) presented significant reductions in the parasite load in distinct organs, when compared to the control groups. An antileishmanial Th1-type cellular and humoral immune response were developed one and 15 days after treatment, with CMt/Mic-treated mice presenting a better protective response. Conclusion: Our data suggest that CMt/Mic could be evaluated as a chemotherapeutic agent against VL.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectDelivery systems-
Palavras-chave: dc.subjectFlavonoids-
Palavras-chave: dc.subjectImmune response-
Palavras-chave: dc.subjectMiltefosine-
Palavras-chave: dc.subjectTreatment-
Título: dc.titleParasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis.-
Aparece nas coleções:Repositório Institucional - UFOP

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