Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBarbosa, Marília Imaculada Frazão-
Autor(es): dc.creatorCorrea, Rodrigo de Souza-
Autor(es): dc.creatorMacedo, Adriana Pereira Mundim Guedes-
Autor(es): dc.creatorGraça, Alex Marchezini-
Autor(es): dc.creatorAndrade, Francyelli Mello-
Autor(es): dc.creatorLeite, Celisnolia Morais-
Autor(es): dc.creatorLacerda, Elisângela de Paula Silveira-
Autor(es): dc.creatorEllena, Javier Alcides-
Autor(es): dc.creatorSilva, Henrique Vieira Reis-
Autor(es): dc.creatorDoriguetto, Antônio Carlos-
Autor(es): dc.creatorBatista, Alzir Azevedo-
Data de aceite: dc.date.accessioned2025-08-21T15:27:58Z-
Data de disponibilização: dc.date.available2025-08-21T15:27:58Z-
Data de envio: dc.date.issued2023-11-23-
Data de envio: dc.date.issued2023-11-23-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/17871-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/inorganics11070270-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1015757-
Descrição: dc.descriptionHerein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6 , where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.-
Palavras-chave: dc.subjectRuthenium-
Palavras-chave: dc.subjectDiphenylphosphine-
Palavras-chave: dc.subjectAmino acids-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectBreast cancer cells-
Título: dc.titleNitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells.-
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