Bioprospection for antiplasmodial activity, and identification of bioactive metabolites of native plants species from the Mata Atlântica biome, Brazil.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorGontijo, Douglas da Costa-
Autor(es): dc.creatorLeite, João Paulo Viana-
Autor(es): dc.creatorNascimento, Maria Fernanda Alves do-
Autor(es): dc.creatorBrandão, Geraldo Célio-
Autor(es): dc.creatorOliveira, Alaíde Braga de-
Data de aceite: dc.date.accessioned2025-08-21T15:27:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:27:22Z-
Data de envio: dc.date.issued2020-05-15-
Data de envio: dc.date.issued2020-05-15-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/12201-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/full/10.1080/14786419.2019.1633645-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/14786419.2019.1633645-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1015362-
Descrição: dc.descriptionA total of 33 extracts of eleven different plants species from Mata Atlântica biome, Brazil, and different fractions of the bioactive extracts were evaluated against chloroquine-resistant Plasmodium falciparum W2 strain by PfLDH method and cytotoxicity to HepG2 cells by the MTT assay, and chemically characterized by LC-DAD-ESI-MS/MS analysis. The results allowed the identification of Alchornea glandulosa, Miconia latecrenata, and Psychotria suterella as the most active plant species. Different flavonoids and tannins in Alchornea glandulosa and Miconia latecrenata besides alkaloids in Psychotria suterella were identified. Bioguided fractionation of A. glandulosa and M. latecrenata leaves extracts led to fractions exhibiting high parasite growth inhibition. Seven known alkaloids were identified in the P. suterella extract, and of these, only 5-carboxystrictosidine had been assayed for antiplasmodial activity what points to this species as the most promising among the eleven one assayed.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectMalaria-
Palavras-chave: dc.subjectChemotaxonomic survey-
Palavras-chave: dc.subjectPlasmodium falciparum-
Palavras-chave: dc.subjectPhytochemical analysis-
Palavras-chave: dc.subjectBioactive extracts-
Título: dc.titleBioprospection for antiplasmodial activity, and identification of bioactive metabolites of native plants species from the Mata Atlântica biome, Brazil.-
Aparece nas coleções:Repositório Institucional - UFOP

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