Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Maísa-
Autor(es): dc.creatorMagalhães, Cíntia Lopes de Brito-
Autor(es): dc.creatorOliveira, Riva de Paula-
Autor(es): dc.creatorSilva, Marcelo Eustáquio-
Autor(es): dc.creatorPedrosa, Maria Lúcia-
Data de aceite: dc.date.accessioned2025-08-21T15:27:18Z-
Data de disponibilização: dc.date.available2025-08-21T15:27:18Z-
Data de envio: dc.date.issued2017-08-11-
Data de envio: dc.date.issued2017-08-11-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/8527-
Fonte completa do material: dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdf-
Fonte completa do material: dc.identifierhttps://doi.org/10.1002/jbt.20418-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1015332-
Descrição: dc.descriptionDiabetes mellitus is associated with altered iron homeostasis that can potentially effect reactive oxygen species generation and contribute to diabetes-related complications. We investigated, by quantitative polymerase chain reaction, whether the expression of liver hepcidin, ferritin, and TfR-1 is altered in diabetes. Rats in the control (C) group received a standard diet; control iron (CI) group received a standard diet supplemented with iron; diabetic (D) group received an injection of streptozotocin; and diabetic iron (DI) group received streptozotocin and the diet with iron.Animals of theDgroup showed higher levels of serum iron, increased concentration of carbonyl protein, and a decrease in antioxidant status. Group D rats showed increased hepatic expression of Trf-1 compared to the other groups. Iron supplementation reversed this increase. Hepcidin mRNA was 81% higher in DI than in C and CI rats. The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf-1 expression.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectCarbonyl iron-
Palavras-chave: dc.subjectStreptozotocin-
Palavras-chave: dc.subjectHepcidin-
Palavras-chave: dc.subjectFerritin-
Título: dc.titleDifferential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver.-
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