Resistance exercise training mitigates cardiac remodeling induced by a high-fat diet in rodents : a systematic review.

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Autor(es): dc.creatorPortes, Alexandre Martins Oliveira-
Autor(es): dc.creatorCosta, Sebastião Felipe Ferreira-
Autor(es): dc.creatorLeite, Luciano Bernardes-
Autor(es): dc.creatorLavorato, Victor Neiva-
Autor(es): dc.creatorMiranda, Denise Coutinho de-
Autor(es): dc.creatorMoura, Anselmo Gomes de-
Autor(es): dc.creatorSoares, Leôncio Lopes-
Autor(es): dc.creatorIsoldi, Mauro César-
Autor(es): dc.creatorNatali, Antônio José-
Data de aceite: dc.date.accessioned2025-08-21T15:26:41Z-
Data de disponibilização: dc.date.available2025-08-21T15:26:41Z-
Data de envio: dc.date.issued2025-03-13-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19929-
Fonte completa do material: dc.identifierhttps://abccardiol.org/en/article/resistance-exercise-training-mitigates-cardiac-remodeling-induced-by-a-high-fat-diet-in-rodents-a-systematic-review/-
Fonte completa do material: dc.identifierhttps://doi.org/10.36660/abc.20230490i-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1014952-
Descrição: dc.descriptionBackground: Obesity is associated with the development of cardiovascular diseases and is a serious public health problem. In animal models, high-fat diet (HFD) feeding impairs cardiac structure and function and promotes oxidative stress and apoptosis. Resistance exercise training (RT), however, has been recommended as coadjutant in the treatment of cardiometabolic diseases, including obesity, because it increases energy expenditure and stimulates lipolysis. Objective: In this systematic review, we aimed to assess the benefits of RT on the heart of rats and mice fed HFD. Methods: Original studies were identified by searching PubMed, Scopus, and Embase databases from December 2007 to December 2022. This study was conducted in accordance with the criteria established by PRISMA and registered in PROSPERO (CRD42022369217). The risk of bias and methodological quality was evaluated by SYRCLE and CAMARADES, respectively. Eligible studies included original articles published in English that evaluated cardiac outcomes in rodents submitted to over 4 weeks of RT and controlled by a sedentary, HFD-fed control group (n = 5). Results: The results showed that RT mitigates cardiac oxidative stress, inflammation, and endoplasmic reticulum stress. It also modifies the activity of structural remodeling markers, although it does not alter biometric parameters, histomorphometric parameters, or the contractile function of cardiomyocytes. Conclusion: Our results indicate that RT partially counteracts the HFD-induced adverse cardiac remodeling by increasing the activity of structural remodeling markers; elevating mitochondrial biogenesis; reducing oxidative stress, inflammatory markers, and endoplasmic reticulum stress; and improving hemodynamic, anthropometric, and metabolic parameters.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: PDF do artigo.-
Palavras-chave: dc.subjectCardiac myocytes-
Palavras-chave: dc.subjectHigh-fat diet-
Palavras-chave: dc.subjectResistance training-
Palavras-chave: dc.subjectSystematic review-
Título: dc.titleResistance exercise training mitigates cardiac remodeling induced by a high-fat diet in rodents : a systematic review.-
Aparece nas coleções:Repositório Institucional - UFOP

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