Sleep deprivation induces genetic damage in mammalian cells : a systematic review.

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Autor(es): dc.creatorSouza, Daniel Vitor de-
Autor(es): dc.creatorRosario, Barbara dos Anjos-
Autor(es): dc.creatorViana, Milena de Barros-
Autor(es): dc.creatorPisani, Luciana Pellegrini-
Autor(es): dc.creatorSilva, Glenda Nicioli da-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T15:26:13Z-
Data de disponibilização: dc.date.available2025-08-21T15:26:13Z-
Data de envio: dc.date.issued2025-02-06-
Data de envio: dc.date.issued2025-02-06-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19724-
Fonte completa do material: dc.identifierhttps://doi.org/10.1590/1806-9282.20231097-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1014667-
Descrição: dc.descriptionSleep is a natural biological state for reducing wakefulness, metabolism, and motor activity characterized by a reversible state and lack of responsiveness to some stimuli1,2. According to the American Academy of Sleep Medicine, the phenomenon can be classified into two stages: non-rapid eye movement (NREM – N1, N2, and N3) sleep stages and rapid eye movement (REM) sleep (R) stage3. Sleep has also been associated with functional brain connectivity and is required for processing information, energy conservation, and restoration4. Sleep deprivation occurs when an individual does not sleep well or even insufficient quantity or low quality of sleep, which leads to a decreasing performance and subsequent deterioration in general health5. This condition can impair several behavioral and biological activities, affecting cognition and mood, increasing fatigue, and decreasing vigor. This picture impairs speed, decision-making, and accuracy of motor tasks6. Although some environmental factors can interfere with the duration as well as the quality of sleep, it is also genetically controlled7. In particular, some studies have demonstrated that sleep deficiency leads to the injury to deoxyribonucleic acid (DNA) in mammalian cells, leading to cellular injury8-10. This is consistent with the idea that sleep loss could induce genotoxicity11. As a result, this systematic review was motivated to answer the following question: Can sleep deprivation induce genetic damage in mammalian cells?-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: PDF do artigo.-
Título: dc.titleSleep deprivation induces genetic damage in mammalian cells : a systematic review.-
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