Assessing levels of uric acid and other cardiovascular markers in prehypertensive and hypertensive adults.

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Autor(es): dc.creatorAgostini, Lívia da Cunha-
Autor(es): dc.creatorSouza, Laura Alves Cota e-
Autor(es): dc.creatorSilva, Nayara Nascimento Toledo-
Autor(es): dc.creatorLopes, Ana Cláudia Faria-
Autor(es): dc.creatorTeixeira, Luiz Fernando de Medeiros-
Autor(es): dc.creatorBelo, Vanessa de Almeida-
Autor(es): dc.creatorVital, Wendel Coura-
Autor(es): dc.creatorSilva, Glenda Nicioli Da-
Autor(es): dc.creatorLima, Angélica Alves-
Data de aceite: dc.date.accessioned2025-08-21T15:25:59Z-
Data de disponibilização: dc.date.available2025-08-21T15:25:59Z-
Data de envio: dc.date.issued2025-02-03-
Data de envio: dc.date.issued2025-02-03-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19697-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1889183724000576-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.hipert.2024.04.003-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1014527-
Descrição: dc.descriptionIntroduction: Although some studies have reported the association between uric acid (UA) and hypertension, evidence on prehypertension is still lacking. Therefore, the objective of this study was to determine the levels of UA and other cardiovascular markers among prehypertensive and hypertensive patients and assess their risk for developing arterial hypertension. Methods: 157 individuals were recruited: 67 normotensive, 23 pre-hypertensive and 67 hypertensive. Blood samples were collected to measure biochemical parameters and anthropometric measurements and blood pressure were evaluated. We calculated the product of lipid accumulation and the visceral adiposity index to assess cardiovascular risk. Results: Our data showed an increase in UA levels in normotensives (4.9 ± 1.3 mg/dL), prehypertensives (5.2 ± 1.3 mg/dL) and hypertensives (5.9 ± 1.6 mg/dL) (p = 0.004). We found a higher frequency of hyperuricemia in the hypertensive group (34.3%) than in the normotensive group (13.4%, p < 0.05). Hypertensive volunteers had lower levels of HDL-C (p = 0.004 and p = 0.003) and higher body mass indexes (p < 0.001 and p = 0.007), glucose (p < 0.001 and p = 0.033), triglycerides (p = 0.001 and p = 0.005), visceral adiposity index (p < 0.001 and p = 0.002) and lipid accumulation product (p < 0.001 and p = 0.007) than normotensive and prehypertensive participants. We also observed that individuals with UA ≥ 6.2 mg/dL had an increased risk of hypertension of 4.77 (p = 0.003) compared to individuals with levels ≤ 4.3 mg/dL.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectUric acid-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectPrehypertension-
Palavras-chave: dc.subjectCardiovascular risk-
Título: dc.titleAssessing levels of uric acid and other cardiovascular markers in prehypertensive and hypertensive adults.-
Aparece nas coleções:Repositório Institucional - UFOP

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