A sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCampos, Débora Priscila de-
Autor(es): dc.creatorBarcellos, Neila Marcia Silva-
Autor(es): dc.creatorMarinho, Flávia Dias Marques-
Autor(es): dc.creatorBarbosa, Guilherme Xavier-
Autor(es): dc.creatorLana, Victoria Luiza Vieira Vidigal-
Autor(es): dc.creatorSouza, Jacqueline de-
Data de aceite: dc.date.accessioned2025-08-21T15:25:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:25:28Z-
Data de envio: dc.date.issued2021-12-05-
Data de envio: dc.date.issued2021-12-05-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/14091-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/abs/10.1080/03639045.2020.1810266-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/03639045.2020.1810266-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1014221-
Descrição: dc.descriptionDonepezil hydrochloride is one of the most prescribed anti-Alzheimer’s drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions in vivo (pH 1.2, 4.5, and 6.8) are not available in the literature. These media are used in the dissolution test, an important tool, for registration and quality control of medicines. Considering the need for methods with this purpose, this work aimed to develop and validate a sustainable UPLC-UV method for quantification of donepezil hydrochloride in tablets, specifically on assay and dissolution profile, with reduced environmental impacts. The proposed method has a run time of 2 min and requires for each run, only 0.8 mL of solvents, providing excellent green analysis. The method proved to be selective, linear, precise, accurate, robust in the range of 2–14 mg/mL. Three products (reference, similar, and generic) were analyzed and showed very rapid dissolution. The average content varied from 100.2 ± 0.6% to 109.5 ± 2.1%. Using dissolution efficiency (DE), the drug release profiles were com pared in different biorelevant media.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectUltra-performance liquid chromatography-
Palavras-chave: dc.subjectGreen analytical method-
Título: dc.titleA sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison.-
Aparece nas coleções:Repositório Institucional - UFOP

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