Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCarraro, Júlia Cristina Cardoso-
Autor(es): dc.creatorHermsdorff, Helen Hermana Miranda-
Autor(es): dc.creatorMansego, Maria Luisa-
Autor(es): dc.creatorZulet, Maria Angeles-
Autor(es): dc.creatorMilagro, Fermín Ignacio-
Autor(es): dc.creatorBressan, Josefina-
Autor(es): dc.creatorMartínez, J. Alfredo-
Data de aceite: dc.date.accessioned2025-08-21T15:24:55Z-
Data de disponibilização: dc.date.available2025-08-21T15:24:55Z-
Data de envio: dc.date.issued2017-10-24-
Data de envio: dc.date.issued2017-10-24-
Data de envio: dc.date.issued2016-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9035-
Fonte completa do material: dc.identifierhttps://www.karger.com/Article/Abstract/448101-
Fonte completa do material: dc.identifierhttps://doi.org/10.1159/000448101-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1013870-
Descrição: dc.descriptionBackground/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Palavras-chave: dc.subjectBiomarker-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectEpigenetics-
Palavras-chave: dc.subjectDNA methylation-
Palavras-chave: dc.subjectDiet-
Título: dc.titleHigher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.-
Aparece nas coleções:Repositório Institucional - UFOP

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