Iron overload potentiates diet-induced hypercholesterolemia and reduces liver ppar-α expression in hamsters.

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Autor(es): dc.creatorBonomo, Larissa de Freitas-
Autor(es): dc.creatorSilva, Maísa-
Autor(es): dc.creatorOliveira, Riva de Paula-
Autor(es): dc.creatorSilva, Marcelo Eustáquio-
Autor(es): dc.creatorPedrosa, Maria Lúcia-
Data de aceite: dc.date.accessioned2025-08-21T15:23:16Z-
Data de disponibilização: dc.date.available2025-08-21T15:23:16Z-
Data de envio: dc.date.issued2017-06-19-
Data de envio: dc.date.issued2017-06-19-
Data de envio: dc.date.issued2012-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7985-
Fonte completa do material: dc.identifierhttps://goo.gl/n6F8PI-
Fonte completa do material: dc.identifierhttps://doi.org/10.1002/jbt.21410-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1012843-
Descrição: dc.descriptionIron stores and lipids are related to the development of cardiovascular disease. Given that peroxisome proliferator-activated receptor alpha (PPAR-α) regulates important physiological processes that impact lipid and glucose homeostasis, we decided to investigate the effects of iron overload on serum lipids and the liver expression of PPAR-α, 3-hydroxy- 3-methylglutaryl coenzyme A reductase, and cholesterol 7α-hydroxylase. Hamsters were divided into four groups. The standard group (S) was fed the AIN-93M diet, the SI group was fed the diet and iron injections, the hypercholesterolemic group (H) was fed a standard diet containing cholesterol, and the HI group was fed a high-cholesterol diet and iron injections. Serum cholesterol in the HI group was higher than in the H group. Gene expression analysis of PPAR-α showed that the HI group had a lower PPAR-α expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR- α expression.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectCholesterol-
Título: dc.titleIron overload potentiates diet-induced hypercholesterolemia and reduces liver ppar-α expression in hamsters.-
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