Functionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCarneiro, Simone Pinto-
Autor(es): dc.creatorCarvalho, Karen Vitor-
Autor(es): dc.creatorSoares, Rodrigo Dian de Oliveira Aguiar-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorAndrade, Milton Hércules Guerra de-
Autor(es): dc.creatorDuarte, Rafael Silva-
Autor(es): dc.creatorSantos, Orlando David Henrique dos-
Data de aceite: dc.date.accessioned2025-08-21T15:22:52Z-
Data de disponibilização: dc.date.available2025-08-21T15:22:52Z-
Data de envio: dc.date.issued2019-03-27-
Data de envio: dc.date.issued2019-03-27-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/10842-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S092777651830883X?via%3Dihub#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1012599-
Descrição: dc.descriptionTuberculosis is an infectious bacterial disease that causes millions of deaths worldwide. Current treatment recommended by WHO is effective, however it is an extensive and arduous process associated to severe adverse effects, which induces a low patient compliance and the emerging of multidrug resistant tuberculosis. Thus, as a main goal of this study, rifampicin nanoparticles were surface functionalized with a tuftsin-modifed peptide to selectively recognize receptors located on infected alveolar macrophages, enhancing nanoparticles uptake by these cells and improving antimycobacterial activity. A tuftsin-based modified peptide was synthesized and successfully attached to nanoparticles interface (NP-pRIF). In parallel, nanoparticles without peptide were also developed for comparison (NP-RIF). Physicochemical characterization demonstrated that stable and monodisperse nanodelivery systems were obtained, with a controlled drug release profile and non-cytotoxic potential. Moreover, nanoparticles containing peptide were significantly more internalized by macrophages than nanoparticles without peptide over a wide range of time. Both nanoparticles were 2-fold more effective against M. tuberculosis than free rifampicin, suggesting NP-pRIF as a promising strategy for the management of tuberculosis treatment.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectModified-tuftsin-
Palavras-chave: dc.subjectTuberculosis-
Título: dc.titleFunctionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity.-
Aparece nas coleções:Repositório Institucional - UFOP

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