Potential role of Carvedilol in the cardiac immune response induced by experimental infection with Trypanosoma cruzi.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorHorta, Aline Luciano-
Autor(es): dc.creatorLeite, Ana Luísa Junqueira-
Autor(es): dc.creatorCosta, Guilherme de Paula-
Autor(es): dc.creatorFigueiredo, Vivian Paulino-
Autor(es): dc.creatorSilva, André Talvani Pedrosa da-
Data de aceite: dc.date.accessioned2025-08-21T15:22:35Z-
Data de disponibilização: dc.date.available2025-08-21T15:22:35Z-
Data de envio: dc.date.issued2017-11-22-
Data de envio: dc.date.issued2017-11-22-
Data de envio: dc.date.issued2017-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/9163-
Fonte completa do material: dc.identifierhttps://doi.org/10.1155/2017/9205062-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1012404-
Descrição: dc.descriptionTrypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of T. cruzi in the acute phase. Animals (𝑛 = 40) were grouped: (i) not infected, (ii) infected, (iii) infected + carvedilol, and (iv) not infected + carvedilol.We analyzed parameters related to parasitemia, plasma levels of TNF, IL-10, and CCL2, and cardiac histopathology after the administration of carvedilol for 30 days. We did not observe differences in the maximum peaks of parasitemia in the day of their detection among the groups. The plasma TNF was elevated at 60 days of infection in mice treated or not with carvedilol. However, we observed a decreased CCL2 level and increased IL-10 levels in those infected animals treated with carvedilol, which impacted the reduction of the inflammatory infiltration in cardiac tissue. For this experimentalmodel, carvedilol therapy was not able to alter the levels of circulating parasites butmodulates the pattern of CCL2 and IL-10 mediators when the VL10 strain of T. cruzi was used in C57BL6 mice.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.-
Título: dc.titlePotential role of Carvedilol in the cardiac immune response induced by experimental infection with Trypanosoma cruzi.-
Aparece nas coleções:Repositório Institucional - UFOP

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