Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSantos, Robson Augusto Souza dos-
Autor(es): dc.creatorSilva, Ana Cristina Simões e-
Autor(es): dc.creatorMaric, Christine-
Autor(es): dc.creatorRabelo, Denise Maria Rover da Silva-
Autor(es): dc.creatorMachado, Raquel do Pilar-
Autor(es): dc.creatorBuhr, Insa de-
Autor(es): dc.creatorWalther, Silvia Heringer-
Autor(es): dc.creatorPinheiro, Sérgio Veloso Brant-
Autor(es): dc.creatorLopes, Miriam Teresa Paz-
Autor(es): dc.creatorBader, Michael-
Autor(es): dc.creatorMendes, Elizabeth Pereira-
Autor(es): dc.creatorLemos, Virgina Soares-
Autor(es): dc.creatorSantos, Maria José Campagnole dos-
Autor(es): dc.creatorSchultheiss, Heinz-Peter-
Autor(es): dc.creatorSpeth, Robert-
Autor(es): dc.creatorWalther, Thomas-
Data de aceite: dc.date.accessioned2025-08-21T15:22:11Z-
Data de disponibilização: dc.date.available2025-08-21T15:22:11Z-
Data de envio: dc.date.issued2017-04-27-
Data de envio: dc.date.issued2017-04-27-
Data de envio: dc.date.issued2003-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7646-
Fonte completa do material: dc.identifierhttp://www.pnas.org/content/100/14/8258.long-
Fonte completa do material: dc.identifierhttps://doi.org/10.1073/pnas.1432869100-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1012138-
Descrição: dc.descriptionThe renin–angiotensin system plays a critical role in blood pressure control and body fluid and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang III [Ang-(2–8)], Ang IV [Ang-(3–8)], and Ang-(1–7) may also have important biological activities. Ang-(1–7) has become an angiotensin of interest in the past few years, because its cardiovascular and baroreflex actions counteract those of Ang II. Unique angiotensin-binding sites specific for this heptapeptide and studies with a selective Ang-(1–7) antagonist indicated the existence of a distinct Ang-(1–7) receptor. We demonstrate that genetic deletion of the G proteincoupled receptor encoded by the Mas protooncogene abolishes the binding of Ang-(1–7) to mouse kidneys. Accordingly, Mas-deficient mice completely lack the antidiuretic action of Ang-(1–7) after an acute water load. Ang-(1–7) binds to Mas-transfected cells and elicits arachidonic acid release. Furthermore, Mas-deficient aortas lose their Ang-(1–7)-induced relaxation response. Collectively, these findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectBinding-
Palavras-chave: dc.subjectMas protooncogene-
Palavras-chave: dc.subjectRenin angiotensin system-
Título: dc.titleAngiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.-
Aparece nas coleções:Repositório Institucional - UFOP

Não existem arquivos associados a este item.