Effects of vascularization on cancer nanochemotherapy outcomes.

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorPaiva, Letícia Ribeiro de-
Autor(es): dc.creatorFerreira Junior, Silvio da Costa-
Autor(es): dc.creatorMartins, Marcelo Lobato-
Data de aceite: dc.date.accessioned2025-08-21T15:21:20Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:20Z-
Data de envio: dc.date.issued2016-11-07-
Data de envio: dc.date.issued2016-11-07-
Data de envio: dc.date.issued2016-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/7077-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.physa.2016.02.065-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1011585-
Descrição: dc.descriptionCancer therapy requires anticancer agents capable of efficient and uniform systemic delivery. One promising route to their development is nanotechnology. Here, a previous model for cancer chemotherapy based on a nanosized drug carrier (Paiva et al., 2011) is extended by including tissue vasculature and a three-dimensional growth. We study through computer simulations the therapy against tumors demanding either large or small nutrient supplies growing under different levels of tissue vascularization. Our results indicate that highly vascularized tumors demand more aggressive therapies (larger injected doses administrated at short intervals) than poorly vascularized ones. Furthermore, nanoparticle endocytic rate by tumor cells, not its selectivity, is the major factor that determines the therapeutic success. Finally, our finds indicate that therapies combining cytotoxic agents with antiangiogenic drugs that reduce the abnormal tumor vasculature, instead of angiogenic drugs that normalize it, can lead to successful treatments using feasible endocytic rates and administration intervals.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsaberto-
Direitos: dc.rightsO periódico Physica A: Statistical Mechanics and its Applications concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3962490612777.-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectTumoral vasculature-
Palavras-chave: dc.subjectNanochemotherapy-
Palavras-chave: dc.subjectMultiscale modeling-
Título: dc.titleEffects of vascularization on cancer nanochemotherapy outcomes.-
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