High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.

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Autor(es): dc.creatorBittencourt, Aline-
Autor(es): dc.creatorBrum, Pedro Ozorio-
Autor(es): dc.creatorRibeiro, Camila Tiefensee-
Autor(es): dc.creatorGasparotto, Juciano-
Autor(es): dc.creatorBortolin, Rafael Calixto-
Autor(es): dc.creatorVargas, Amanda Rodrigues de-
Autor(es): dc.creatorHeimfarth, Luana-
Autor(es): dc.creatorAlmeida, Roberto Farina de-
Autor(es): dc.creatorMoreira, José Claudio Fonseca-
Autor(es): dc.creatorOliveira, Jade de-
Autor(es): dc.creatorGelain, Daniel Pens-
Data de aceite: dc.date.accessioned2025-08-21T15:20:25Z-
Data de disponibilização: dc.date.available2025-08-21T15:20:25Z-
Data de envio: dc.date.issued2023-05-10-
Data de envio: dc.date.issued2023-05-10-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/jspui/handle/123456789/16547-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/full/10.1080/1028415X.2020.1831261-
Fonte completa do material: dc.identifierhttps://doi.org/10.1080/1028415X.2020.1831261-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1011074-
Descrição: dc.descriptionObesity is a health problem that has been associated with neuroinflammation, decreased cognitive functions and development of neurodegenerative diseases. Parkinson’s disease (PD) is a chronic neurodegenerative condition characterized by motor and non-motor abnormalities, increased brain inflammation, α-synuclein protein aggregation and dopaminergic neuron loss that is associated with decreased levels of tyrosine hydroxylase (TH) in the brain. Diet-induced obesity is a global epidemic and its role as a risk factor for PD is not clear. Herein, we showed that 25 weeks on a high-fat diet (HFD) promotes significant alterations in the nigrostriatal axis of Wistar rats. Obesity induced by HFD exposure caused a reduction in TH levels and increased TH phosphorylation at serine 40 in the ventral tegmental area. These effects were associated with insulin resistance, increased tumor necrosis factor-α levels, oxidative stress, astrogliosis and microglia activation. No difference was detected in the levels of α-synuclein. Obesity also induced impairment of locomotor activity, total mobility and anxiety-related behaviors that were identified in the open-field and light/dark tasks. There were no changes in motor coordination or memory. Together, these data suggest that the reduction of TH levels in the nigrostriatal axis occurs through an α-synuclein-independent pathway and can be attributed to brain inflammation, oxidative/nitrosative stress and metabolic disorders induced by obesity.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectParkinson’s disease-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectLocomotion-
Palavras-chave: dc.subjectAnxiety-
Título: dc.titleHigh fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.-
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