Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy.

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Autor(es): dc.creatorGonzález Lozano, Kelly Joanna-
Autor(es): dc.creatorSantos, Elda Gonçalves dos-
Autor(es): dc.creatorVilas Boas, Diego Fernandes-
Autor(es): dc.creatorOliveira, Raphaela da Rocha Gaban de-
Autor(es): dc.creatorDiniz, Lívia de Figueiredo-
Autor(es): dc.creatorBenedetti, Monique Dias-
Autor(es): dc.creatorCarneiro, Cláudia Martins-
Autor(es): dc.creatorBandeira, Lorena Cera-
Autor(es): dc.creatorFaria, Gilson-
Autor(es): dc.creatorGonçalves, Reggiani Vilela-
Autor(es): dc.creatorNovaes, Rômulo Dias-
Autor(es): dc.creatorCaldas, Sérgio-
Autor(es): dc.creatorCaldas, Ivo Santana-
Data de aceite: dc.date.accessioned2025-08-21T15:19:22Z-
Data de disponibilização: dc.date.available2025-08-21T15:19:22Z-
Data de envio: dc.date.issued2025-02-04-
Data de envio: dc.date.issued2025-02-04-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19705-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1567576923017940-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.intimp.2023.111467-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1010388-
Descrição: dc.descriptionThe adequate management of parasite co-infections represents a challenge that has not yet been overcome, especially considering that the pathological outcomes and responses to treatment are poorly understood. Thus, this study aimed to evaluate the impact of Schistosoma mansoni infection on the efficacy of benznidazole (BZN)- based chemotherapy in Trypanosoma cruzi co-infected mice. BALB/c mice were maintained uninfected or coinfected with S. mansoni and T. cruzi, and were untreated or treated with BZN. Body weight, mortality, parasitemia, cardiac parasitism, circulating cytokines (Th1/Th2/Th17); as well as heart, liver and intestine microstructure were analyzed. The parasitemia peak was five times higher and myocarditis was more severe in coinfected than T. cruzi-infected mice. After reaching peak, parasitemia was effectively controlled in co-infected animals. BZN successfully controlled parasitemia in both co-infected and T. cruzi-infected mice and improved body mass, cardiac parasitism, myocarditis and survival in co-infected mice. Co-infection dampened the typical cytokine response to either parasite, and BZN reduced anti-inflammatory cytokines in co-infected mice. Despite BZN normalizing splenomegaly and liver cellular infiltration, it exacerbated hepatomegaly in co-infected mice. Co-infection or BZN exerted no effect on hepatic granulomas, but increased pulmonary and intestinal granulomas. Marked granulomatous inflammation was identified in the small intestine of all schistosomiasis groups. Taken together, our findings indicate that BZN retains its therapeutic efficacy against T. cruzi infection even in the presence of S. mansoni co-infection, but with organ-specific repercussions, especially in the liver.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectAntiparasitic chemotherapy-
Palavras-chave: dc.subjectExperimental parasitology-
Palavras-chave: dc.subjectExperimental pathology-
Palavras-chave: dc.subjectSchistosomiasis-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleSchistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy.-
Aparece nas coleções:Repositório Institucional - UFOP

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