Treatment using vanillin-derived synthetic molecules incorporated into polymeric micelles is effective against infection caused by Leishmania amazonensis species.

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Autor(es): dc.creatorPereira, Isabela Amorim Gonçalves-
Autor(es): dc.creatorFreitas, Camila Simões de-
Autor(es): dc.creatorCâmara, Raquel Soares Bandeira-
Autor(es): dc.creatorJesus, Marcelo Moreira de-
Autor(es): dc.creatorLage, Daniela Pagliara-
Autor(es): dc.creatorTavares, Grasiele de Sousa Vieira-
Autor(es): dc.creatorSoyer, Tauane Gonçalves-
Autor(es): dc.creatorRamos, Fernanda Fonseca-
Autor(es): dc.creatorSoares, Nícia Pedreira-
Autor(es): dc.creatorSantiago, Samira Soares-
Autor(es): dc.creatorMartins, Vívian Tamietti-
Autor(es): dc.creatorVale, Danniele Luciana-
Autor(es): dc.creatorSantos, Breno Luiz Pimenta dos-
Autor(es): dc.creatorRibeiro, Fernanda Ludolf-
Autor(es): dc.creatorOliveira, Fabrício Marques de-
Autor(es): dc.creatorDuarte, Mariana Costa-
Autor(es): dc.creatorChávez Fumagalli, Miguel Angel-
Autor(es): dc.creatorCosta, Adilson Vidal-
Autor(es): dc.creatorGonçalves, Denise Utsch-
Autor(es): dc.creatorRoatt, Bruno Mendes-
Autor(es): dc.creatorTeixeira, Róbson Ricardo-
Autor(es): dc.creatorCoelho, Eduardo Antônio Ferraz-
Data de aceite: dc.date.accessioned2025-08-21T15:18:34Z-
Data de disponibilização: dc.date.available2025-08-21T15:18:34Z-
Data de envio: dc.date.issued2025-02-27-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttps://www.repositorio.ufop.br/handle/123456789/19812-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0014489424000468-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.exppara.2024.108743-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1009947-
Descrição: dc.descriptionTreatment against leishmaniasis presents problems, mainly due to the toxicity of the drugs, high cost, and the emergence of resistant strains. A previous study showed that two vanillin-derived synthetic molecules, 3s [4-(2- hydroxy-3-(4-octyl-1H-1,2,3-triazol-1-yl)propoxy)-3-methoxybenzaldehyde] and 3t [4-(3-(4-decyl-1H-1,2,3-triazol-1-yl)-2-hydroxypropoxy)-3-methoxybenzaldehyde], presented antileishmanial activity against Leishmania infantum, L. amazonensis, and L. braziliensis species. In the present work, 3s and 3t were evaluated to treat L. amazonensis-infected mice. Molecules were used pure or incorporated into Poloxamer 407-based micelles. In addition, amphotericin B (AmpB) and its liposomal formulation, Ambisome®, were used as control. Animals received the treatment and, one and 30 days after, they were euthanized to evaluate immunological, parasitological, and biochemical parameters. Results showed that the micellar compositions (3s/Mic and 3t/Mic) induced significant reductions in the lesion mean diameter and parasite load in the infected tissue and distinct organs, as well as a specific and significant antileishmanial Th1-type immune response, which was based on significantly higher levels of IFN-γ, IL-12, nitrite, and IgG2a isotype antibodies. Drug controls showed also antileishmanial action; although 3s/Mic and 3t/Mic have presented better and more significant parasitological and immunological data, which were based on significantly higher IFN-γ production and lower parasite burden in treated animals. In addition, significantly lower levels of urea, creatinine, alanine transaminase, and aspartate transaminase were found in mice treated with 3s/Mic and 3t/Mic, when compared to the others. In conclusion, results suggest that 3s/ Mic and 3t/Mic could be considered as therapeutic candidates to treat against L. amazonensis infection.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsrestrito-
Palavras-chave: dc.subjectTegumentary leishmaniasis-
Palavras-chave: dc.subjectTreatment-
Palavras-chave: dc.subjectVanillin-
Palavras-chave: dc.subjectAmphotericin B-
Palavras-chave: dc.subjectLeishmania amazonensis-
Título: dc.titleTreatment using vanillin-derived synthetic molecules incorporated into polymeric micelles is effective against infection caused by Leishmania amazonensis species.-
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